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FLASH GENE
Symbol KRT10 contributors: mct/npt - updated : 11/09/2008
HGNC name keratin 10
HGNC id 6413
Corresponding disease
CIEHK ichthiosis cyclic, with epidermolytic hyperkeratosis
EHK2 epidermolytic hyperkeratosis 2
Location 17q21.3      Physical location : 38.974.369 - 38.978.863
Synonym name
  • cytokeratin 10
  • keratin, type I cytoskeletal 10
  • keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)
  • keratosis palmaris et plantaris
  • epidermolytic hyperkeratosis
  • Synonym symbol(s) KPP, CK10, K10
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 4.50 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2162 - 584 - Ivanova (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveesophagus   highly
     liver   highly
     pharynx   highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningepidermisstratum spinosum 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentcornified cell
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved a central rod domain, with four helical domains (1A, 1B, 2A, 2B)
  • non alpha helical linkers (L1, 2, 3)
  • homology domain H1
  • variable region (V1, V2) and end sequences (E1, E2)
  • mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • intermediate filament family
  • type I keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • heteropolymeric structural proteins which form the intermediate filament
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with KRT1, KRT9
  • heterotetramer of two type I and two type II keratins, keratin 10 is generally associated with keratin I
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EHK2 , CIEHK
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS