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FLASH GENE
Symbol KREMEN2 contributors: mct/npt - updated : 04/10/2008
HGNC name kringle containing transmembrane protein 2
HGNC id 18797
Location 16p13.3      Physical location : 3.014.216 - 3.018.380
Synonym name
  • kringle-containing protein marking the eye and the nose
  • Dickkopf receptor 2
    • Synonym symbol(s) KRM2, MGC10791, MGC16709
    DNA
    TYPE functioning gene
    STRUCTURE 4.16 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing codon stop 2276 46.6 424 - Mao
    containing an additional segment in the 3' coding region producing a frameshift
    8 splicing codon stop 1992 46.2 420 - Mao (2002)
    lacking an exon in the 3' coding region
    - splicing codon stop 2356 43.9 399 - Mao
    containing an additional segment in the 3' coding region producing a frameshift
    9 splicing codon stop 2071 48.9 462 - Mao (2002)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Reproductivefemale systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • a kringle domain
  • a WSC
  • a CUB domain and four glycosylation sites in the extracellular region
    • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • DKK receptor, cooperating with DKK1 to block WNT, beta catenin signaling pathway
  • inducing exocytosis, cell cell interaction
  • not universally required for DKK1 function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , cell to cell transport , exocytosis transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of a ternary complex with DKK1 and the lipoprotein related protein - (LRP6)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to LRP6, KREMEN1
  • with KREMEN1, identified to be the high-affinity receptors for Dickkopf (Dkk), the inhibitor of Wnt/beta-catenin signalling
  • functional interaction of Kremen proteins with DKK1 as negative regulators of Wnt/beta-catenin signaling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS