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FLASH GENE
Symbol KMT5C contributors: mct/npt - updated : 15-06-2018
HGNC name lysine methyltransferase 5C
HGNC id 28405
Location 19q13.42      Physical location : -
Synonym name
  • lysine N-methyltransferase 5C
  • Su(var)4-20 homolog 2
  • suppressor of variegation 4-20 homolog 2 (Drosophila)
  • Synonym symbol(s) MGC2705, , FLJ98627, Suv4-20h2, SUV420H2
    EC.number 2.1.1.43
    DNA
    TYPE functioning gene
    STRUCTURE 8.27 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2318 - 462 - Schotta (2004)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 88 Aas region, the heterochromatic targeting module, recapitulates both, CBX binding and strong association to heterochromatin (Souza 2009)
  • HOMOLOGY
    Homologene
    FAMILY
  • histone-lysine methyltransferase family
  • Suvar4-20 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    text strongly associated to pericentric heterochromatin (Souza 2009)
    basic FUNCTION
  • histone methyltransferases activity (Schotta 2004)
  • may be recruited to heterochromatin in association with CBX1, CBX3, CBX5, and stably maintained at its heterochromatin sites in an CBX-independent fashion (Souza 2009)
  • KMT5B, KMT5C differ substantially in their localization and activity
  • can induce a transition from H4K20me1 to H4K20me3 in regions of constitutive heterochromatin that is sufficient to enhance myogenic differentiation, suggesting it can act an as epigenetic 'switch' in this process
  • KMT5B, KMT5C are two highly homologous enzymes that methylate lysine 20 of histone H4 (H4K20), a mark that has been implicated in transcriptional regulation
  • is required for matrix mineralization during osteoblast differentiation, and controls the H4K20 methylome of osteoblasts and is critical for normal progression of osteoblastogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • recruited to heterochromatin in association with CBX1, CBX3, CBX5, and stably maintained at its heterochromatin sites in an CBX-independent fashion (Souza 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS