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FLASH GENE
Symbol KLRD1 contributors: mct/npt - updated : 21-05-2014
HGNC name killer cell lectin-like receptor subfamily D, member 1
HGNC id 6378
Location 12p13.2      Physical location : 10.457.049 - 10.469.849
Synonym name
  • cell differentiation antigen CD94, NK cell, T-cell (subset), 43kD, identified by monoclonal antibody HP3B1
  • CD94 antigen
  • NK cell receptor
  • Synonym symbol(s) CD94, KP43
    DNA
    TYPE functioning gene
    STRUCTURE 12.80 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure regulated by distal and proximal promoters that transcribe unique initial exons specific to each promoter (distal and proximal promoters both contain elements with IFN-gamma-activated and Ets binding sites, known as GAS/EBS) (Lieto 2003)
    MAPPING cloned Y linked N status confirmed
    Map pter - CD69 - CLEC2B - D12S1093 - D12S842 - KLRF1 - D12S1839 - D12S1674 - D12S1690 - OLR1 - D12S1275 - D12S1696 - D12S77 - D12S1916 - KLRD1 - KLRK1 - D12S1900 - KLRA1 - cen
    Authors Renedo (00)
    Physical map
    LOC374443 12p13.31 CLR pseudogene LLT1 12p13 CLR pseudogene LOC387835 12 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 DCAL1 12p13.31 dendritic cell-associated lectin-1 CD69 12p13.2-p13.1 CD69 antigen (p60, early T-cell activation antigen) LOC390293 12 similar to ACRC protein; putative nuclear protein KLRF1 12p13.3-p13.2 killer cell lectin-like receptor subfamily F, member 1 CLECSF2 12p13.2-p13.1 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 2 (activation-induced) LOC387836 12 similar to INPE5792 CLL-1 CLEC2 12p13.31 C-type lectin-like receptor-2 LOC387837 12 similar to macrophage antigen h LOC283420 12p13.31 similar to HEEE9341 CLEC1 12p13.31 C-type lectin-like receptor-1 LOC390294 12 similar to HNRPAB protein CLECSF12 12p13.2-p12.3 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 OLR1 12p13.1-p12.3 oxidised low density lipoprotein (lectin-like) receptor 1 FLJ31166 12p13.31 hypothetical protein FLJ31166 GABARAPL1 12p12.3 GABA(A) receptor-associated protein like 1 KLRD1 12p13.2-p13.1 killer cell lectin-like receptor subfamily D, member 1 KLRK1 12p13.2-p13.1 killer cell lectin-like receptor subfamily K, member 1 KLRC4 12p13.2-p13.1 killer cell lectin-like receptor subfamily C, member 4 KLRC3 12p13.2-p13.1 killer cell lectin-like receptor subfamily C, member 3 KLRC2 12p13.2-p13.1 killer cell lectin-like receptor subfamily C, member 2 KLRC1 12p13.2-p13.1 killer cell lectin-like receptor subfamily C, member 1 LOC255308 12p13.31 similar to eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa; eukaryotic translation initiation factor 2G; eukaryotic translation initiation factor 2, subunit 3 (gamma, 52kD) KLRA1 12p13.2-p13.1 killer cell lectin-like receptor subfamily A, member 1 FLJ10292 12p13.31 hypothetical protein FLJ10292 DKFZp761P1010 12p13.31 hypothetical protein DKFZp761P1010 CSDA 12p13.1 cold shock domain protein A LOC387838 12 LOC387838 TAS2R7 12p13 taste receptor, type 2, member 7 TAS2R8 12p13 taste receptor, type 2, member 8 TAS2R9 12p13 taste receptor, type 2, member 9 TAS2R10 12p13 taste receptor, type 2, member 10 PROL4 12p13 proline rich 4 (lacrimal) PRH1 12p13.2 proline-rich protein HaeIII subfamily 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3258 - 179 - Lieto, Higai (2009)
    5 - 3165 - 148 - Lieto, Higai (2009)
    7 - 3195 - 179 - Higai (2009)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta   
     male systemtestis   
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunenatural killer Homo sapiens
    Lymphoid/ImmuneT cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C terminal carbohydrate recognition domain homologous with the C type lectin family member, group V, like Ly-49
  • mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • natural killer cell lectin-like receptor subfamily D
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text type II integral membrane protein
    basic FUNCTION
  • involved in HLA-E recognition (NKG2@)
  • playing a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells
  • C-type lectin required for the dimerization of the CD94/NKG2 family of receptors, which are expressed on NK cells and T cell subsets (Lieto 2003)
  • KLRD1/KLRC1 utilizes a previously undescribed endocytic mechanism coupled with an abbreviated trafficking pattern, perhaps to insure surface expression (Masilamani 2008)
  • killer lectin-like receptor on natural killer cells triggering cytotoxicity through binding of glycans on target cells including sialyl Lewis X antigen (Higai 2009)
  • peptide-selective NK cell receptor, and NK cells can be regulated by nonsignaling interactions
  • two distinct inhibitory receptor systems for MHC class I, one of which is KLRD1–KLRC1
  • in the absence of KLRC1, has a distinct specificity for HLA-E–peptide complexes
  • KLRC1 and KLRD1 operates in tandem with the polymorphic killer cell Ig-like receptors (KIR) and Ly49 systems to inhibit NK cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with KLRC1, KLRC2 or KLRC3, NKG2D, NKG2F glycoproteins in NK cell receptor (Imaizumi 2009)
  • KLRD1 forms disulfide-bonded heterodimers with the KLRC1 subunit to form an inhibitory receptor or with the KLRC2 or KLRC3 subunits to assemble a receptor complex with activating DAP12 signaling proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with TYROB
  • interacting with KLRK1 (KLRK1 and KLRD1 bind to heparin and sulfate-containing polysaccharides) (Higai 2009)
  • ligand for KLRK1/KLRC1, KLRC2 is leukocyte antigen (HLA)-E, which is constitutively expressed on human cells (Imaizumi 2009)
  • bind to heparin and sulfate-containing polysaccharides (this binding is interesting for natural immunity in cancer progression and metastasis)(Higai 2009)
  • covalently associate to activating or inhibitory NKG2 molecules, and their expression finely tunes cell responses
  • expression of KLRD1 and its associated KLRC1, KLRC2, KLRC3 subunits is dispensable for NK cell development, education, and many NK cell functions
  • receptor that binds HLA-E in a peptide-dependent fashion
  • KLRC3 is capable of associating with KLRD1 and TYROBP but the complex was retained intracellularly at the endoplasmic reticulum instead of being expressed on cell surfaces, and this localization was dependent on a sequence of hydrophobic AAs in the extracellular domain of KLRC3
  • cell & other
    REGULATION
    Other calcineurin-dependent negative regulation of KLRD1/KLRC1 expression on naive CD8+ T cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS