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FLASH GENE

Symbol

KLRC4

contributors: - updated : 04-01-2006

HGNC name	killer cell lectin-like receptor subfamily C, member 4
HGNC id	6377

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12p13.2-p13.1      Physical location : 10.559.984 - 10.562.356
Synonym name	NKG2-D type II integral membrane protein
Synonym symbol(s)	NKG2F

DNA

TYPE	functioning gene
SPECIAL FEATURE	overlapping, gene in gene
text	the 3' end includes the first non coding exon of D12S2489E
STRUCTURE	2.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic NK cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an extracytoplasmic carbohydrate recognition domain homologous with the C type lectin family member, group V
	an extracellular domain (62 residues) that is truncated relative to other NKG2 molecules
	both a positively charged residue in its transmembrane region
	an intracellular ITIM-like sequence

HOMOLOGY

Homologene

FAMILY

natural killer cell lectin-like receptor subfamily C

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	type II integral membrane protein

basic FUNCTION	triggering target cell lysis by NK cells
	may play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells
	receptor component with an as yet unidentified partner(s), may be regulating cell activation through competition for TYROBP with other receptors, such as NKG2C and -E/H, or may be simply vestigial gene product

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	cellular defense receptor

PATHWAY

metabolism

signaling

a component	constituent with HCST of an activating complex receptor for MICA
	forming an heterodimer with the CD94 receptor (KLRD1)

INTERACTION

DNA

RNA

small molecule

protein

associating with TYROBP, thereby providing activation signaling potential

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS