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FLASH GENE
Symbol KLRC3 contributors: mct - updated : 23-05-2014
HGNC name killer cell lectin-like receptor subfamily C, member 3
HGNC id 6376
Location 12p13.31      Physical location : 10.564.917 - 10.573.194
Synonym symbol(s) NKG2E, NKG2-E
DNA
TYPE functioning gene
STRUCTURE 8.28 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1042 - 240 - 2005 15843571
6 - 843 - 257 - 2005 15843571
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extracytoplasmic carbohydrate recognition domain homologous with the C type lectin family member, group V,
  • absence of cytoplasmic tyrosine based inhibitory motif (ITIM)
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY natural killer cell lectin-like receptor subfamily C
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • triggering target cell lysis by NK cells
  • playing a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells
  • cluster of flanking transcription factors collaborate with ER to induce a functional ERE in the KLRC3 promoter
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming an heterodimer with the CD94 receptor (KLRD1)
  • KLRD1 forms disulfide-bonded heterodimers with the KLRC1 subunit to form an inhibitory receptor or with the KLRC2 or KLRC3 subunits to assemble a receptor complex with activating DAP12 signaling proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with TYROBP, via a positively charged residue in their transmembrane domains and function as activation receptor
  • capable of associating with KLRD1 and TYROBP but the complex was retained intracellularly at the endoplasmic reticulum instead of being expressed on cell surfaces, and this localization was dependent on a sequence of hydrophobic AAs in the extracellular domain of KLRC3
  • cell & other
    REGULATION
    Other regulated by E2, tamoxifen, and raloxifene
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS