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FLASH GENE
Symbol KLK6 contributors: mct/pgu - updated : 21-02-2010
HGNC name kallikrein-related peptidase 6
HGNC id 6367
Location 19q13.33      Physical location : 51.461.887 - 51.472.929
Synonym name
  • neurosin, zyme, protease serine 9
  • kallikrein 6 (neurosin, zyme)
  • protease, serine, 18
  • protease M
  • Synonym symbol(s) PRSS9, KLK9, ZYME, Bssp, Klk7, MGC9355, NEUROSIN, PRSS18, SP59
    EC.number 3.4.21.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text tightly clustered multigene family on chromosome 19q13.4
    STRUCTURE 11.04 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D19S412 - D19S596 - D19S907 - KLK1 - KLK3 - KLK2 - KLK4 - KLK5 - KLK6 - KLK12 - KLK13 - KLK14 - KLK6 - KLK7 - KLK8 - KLK9 - KLK10 - KLK11 - D19S571- D19S927 - D19S418 - qter
    Physical map
    SYT3 19q13.4 synaptotagmin III LOC342918 19q13.41 hypothetical LOC342918 SHANK1 19q13.3 SH3 and multiple ankyrin repeat domains 1 SCGF 19q13.3 stem cell growth factor; lymphocyte secreted C-type lectin GPR32P 19q13.3 G protein-coupled receptor 32, pseudogene GPR32 19q13.3 G protein-coupled receptor 32 ACPT 19q13.4 acid phosphatase, testicular MGC13170 19q13.41 multidrug resistance-related protein MGC45922 19q13.41 hypothetical gene MGC45922 KLK1 19q13.4 kallikrein 1, renal/pancreas/salivary KLK15 19q13.4 kallikrein 1, renal/pancreas/salivary KLK3 19q13.3 kallikrein 3, (prostate specific antigen) KLK2 19q13.4 kallikrein 2, prostatic KLK4 19q13.3-q13.4 kallikrein 4 (prostase, enamel matrix, prostate) LOC390956 19 similar to peptidyl-Pro cis trans isomerase KLK5 19q13.3-q13.4 kallikrein 5 KLK6 19q13.3 kallikrein 6 (neurosin, zyme) KLK7 19q13.41 kallikrein 7 (chymotryptic, stratum corneum) KLK8 19q13.3 kallikrein 8 (neuropsin/ovasin) KLK9 19q13.3-q13.4 kallikrein 9 KLK10 19q13.3 kallikrein 10 KLK11 19q13.3-q13.4 kallikrein 11 KLK12 19q13.3-q13.4 kallikrein 12 KLK13 19q13.2-q13.4 kallikrein 13 KLK14 19q13.3-q13.4 kallikrein 14 LOC90353 19q13.41 LOC90353 SIGLEC9 19q13.4 sialic acid binding Ig-like lectin 9 SIGLEC7 19q13.3 sialic acid binding Ig-like lectin 7 LOC284367 19q13.41 hypothetical protein LOC284367 SIGLECP1 19q13.33 sialic acid binding Ig-like lectin, pseudogene 1 CD33 19q13.3 CD33 antigen (gp67)
    regionally located clustered with kallikrein gene family
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1527 - 244 - 1999 10610719
    multiple transcriptional start sites exist for variant B
    5 - 1495 - 137 - 1999 10610719
    7 - 1527 - 244 - 1999 10610719
    has a distinct C-terminus when it is compared to isoform A
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum   Homo sapiens
     spinal cord    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Homo sapiens
    cell lineage
    cell lines primary mammary carcinoma lines, prostate, ovarian
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • trypsin domain
  • a peptidase S1 domain
  • HOMOLOGY
    interspecies homolog to murine Klk29
    Homologene
    FAMILY
  • peptidase S1 family
  • Kallikrein subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • might play a role in tissue remodeling and/or tumor invasion and metastasis
  • involved in desquamation cascade of the skin
  • as other KLKs may participate in desquamation through cleavage of desmoglein 1 and regulation by LEKTI
  • may play a crucial role in promoting cancer-cell invasion in bladder tumor
  • trypsin-like serine peptidase, having oncogenic role of KLK6 in colorectal cancer
  • exhibit trypsin-like specificity, with a strong preference for Arg at the P1 position of substrates
  • oncogenic role of KLK6 in colorectal cancer
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by steroid hormones
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in cerebrospinal fluid and plasma in Alzheimer diseases
    tumoral     --over  
    in gastric cancer
    tumoral     --low  
    in breast and ovarian cancer, metastatic
    tumoral     --over  
    significantly increased in invasive cancers relative to normal ovaries
    tumoral     --over  
    in papillary renal cell carcinoma
    tumoral     --over  
    of KLK6 and KLK13 in ovarian cancer compared to normal ovarian tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • potential biomarkers that can significantly predict prognosis in terms of recurrence-free survival and overall survival in ovarian cancer
  • high concentration of KLK6 is an indicator of tumor proliferation and an independent predictive factor in non-small cell lung cancer
  • Marker potential biomarkers in ovarian cancer
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    potential therapeutic targets for treatment of ovarian cancer (PMID: 19707197)
    dermatologyskin 
    potential target for the treatment of skin disorders in which KLK activity is elevated
    cancerreproductiveovary
    may be therapeutic targets for treatment of ovarian cancer
    ANIMAL & CELL MODELS