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FLASH GENE
Symbol KLK12 contributors: mct - updated : 23-05-2012
HGNC name kallikrein 12
HGNC id 6360
Location 19q13.33      Physical location : 51.532.347 - 51.538.148
Synonym name neuropsin, kallikrein like 5
Synonym symbol(s) KLK-L5, KLKC, KLKL5, DKFZp686H1078, MGC42603
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text tightly clustered multigene family on chromosome 19q13.4
STRUCTURE 5.80 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC342918 19q13.41 hypothetical LOC342918 SHANK1 19q13.3 SH3 and multiple ankyrin repeat domains 1 SCGF 19q13.3 stem cell growth factor; lymphocyte secreted C-type lectin GPR32P 19q13.3 G protein-coupled receptor 32, pseudogene GPR32 19q13.3 G protein-coupled receptor 32 ACPT 19q13.4 acid phosphatase, testicular MGC13170 19q13.41 multidrug resistance-related protein MGC45922 19q13.41 hypothetical gene MGC45922 KLK1 19q13.4 kallikrein 1, renal/pancreas/salivary KLK15 19q13.4 kallikrein 1, renal/pancreas/salivary KLK3 19q13.3 kallikrein 3, (prostate specific antigen) KLK2 19q13.4 kallikrein 2, prostatic KLK4 19q13.3-q13.4 kallikrein 4 (prostase, enamel matrix, prostate) LOC390956 19 similar to peptidyl-Pro cis trans isomerase KLK5 19q13.3-q13.4 kallikrein 5 KLK6 19q13.3 kallikrein 6 (neurosin, zyme) KLK7 19q13.41 kallikrein 7 (chymotryptic, stratum corneum) KLK8 19q13.3 kallikrein 8 (neuropsin/ovasin) KLK9 19q13.3-q13.4 kallikrein 9 KLK10 19q13.3 kallikrein 10 KLK11 19q13.3-q13.4 kallikrein 11 KLK12 19q13.3-q13.4 kallikrein 12 KLK13 19q13.2-q13.4 kallikrein 13 KLK14 19q13.3-q13.4 kallikrein 14 LOC90353 19q13.41 LOC90353 SIGLEC9 19q13.4 sialic acid binding Ig-like lectin 9 SIGLEC7 19q13.3 sialic acid binding Ig-like lectin 7 LOC284367 19q13.41 hypothetical protein LOC284367 SIGLECP1 19q13.33 sialic acid binding Ig-like lectin, pseudogene 1 CD33 19q13.3 CD33 antigen (gp67) FLJ40235 19q13.41 hypothetical protein FLJ40235 LOC339351 19q13.41 similar to hypothetical protein LOC162952 19q13.41 similar to Opioid binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML) LOC147645 19q13.41 hypothetical protein LOC147645 ETFB 19q13.4 electron-transfer-flavoprotein, beta polypeptide
regionally located clustered with kallikrein gene family
RNA
TRANSCRIPTS type messenger
text
  • five coding exons and one 5prime-untranslated exon with at least four alternatively spliced forms known to date (PMID: 21628462)
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 1074 26.7 248 - 2000 10766816
    5 - 814 12 111 .globular proteinú.salivary gland, stomach, uterus, trachea, prostate, thymus, lung, colon, breast, brain, thyroid gland and others 2000 10766816
    exon 4 missing
    7 splicing 945 27.1 254 .salivary gland, stomach, uterus, trachea, prostate, thymus, lung, colon, breast, brain, thyroid gland and others 2000 10766816
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     salivary gland   highly Homo sapiens
     stomach   highly Homo sapiens
    Reproductivemale systemprostate  highly Homo sapiens
    Respiratorylung   highly Homo sapiens
     respiratory tracttrachea  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly Homo sapiens
    Connectivebone  highly Homo sapiens
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion salivary gland
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    isoforms Precursor secreted as an inactive pro-enzyme, which is able to autoactivate to gain enzymatic activity
    HOMOLOGY
    interspecies homolog to murine neuropsin
    Homologene
    FAMILY kallikrein gene family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in pathogenesis and/or progression of certain cancer types
  • possesses trypsin-like activity, cleaving peptide bonds after both arginine and lysine
  • may participate in enzymatic cascades involving other kallikreins
  • may indirectly regulate the bioavailability and activity of several growth factors through processing of their CCN binding partners
  • involvement of KLK12 in different homeostatic and disease pathways through modulation of growth factor availability and/or activity
  • play a critical role in controlling normal angiogenesis
  • KLK12-mediated proteolysis of CYR61 and WISP3 can reduce or abolish the binding of VEGFA, BMP2, and TGFB1
  • KLK12-mediated hydrolysis of CCNs may be involved in the modulation of the bioavailability and/or activity of several growth factors including VEGFA, BMP2, TGFB1, and FGF2
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • might be responsible for the shedding of CYR61 from the cell surface
  • can target all six members of the CCN family at different proteolytic sites (WISP1, WISP2, WISP3, CYR61, CTGF, NOV)
  • interacting with CYR61 and WISP3 (fragmentation of CYR61 and WISP3 by KLK12 on cells of the tumor microenvironment, including neoplastic and endothelial cells)
  • cell & other
    REGULATION
    induced by steroid hormone
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer
    tumoral     --over  
    in prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may have potential use as a cancer biomarker
  • Therapy target
    ANIMAL & CELL MODELS