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FLASH GENE

Symbol

KLHL25

contributors: mct - updated : 14-06-2021

HGNC name	kelch-like 25 (Drosophila)
HGNC id	25732

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q25.3      Physical location : 86.302.560 - 86.338.189
Synonym name	ectoderm-neural cortex protein 2
	BTB/POZ KELCH domain protein
	kelch-like protein 25
Synonym symbol(s)	FLJ12587, ENC2, ENC-2, FLJ45015

DNA

TYPE	functioning gene
STRUCTURE	35.63 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_022480 3 - 3683 NP_071925 - 589 - 2016 27664236

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth         Nervous brain         Reproductive male system testis       Respiratory respiratory tract trachea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

kelch repeat domain

HOMOLOGY

interspecies	homolog to murine Klhl25 (94.9pc)
	homolog to rattus Klhl25 (94.7pc)

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION

KLHL25-CUL3 complex is the E3 ubiquitin ligase, which targets hypophosphorylated EIF4EBP1

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

CUL3 interacts with ACLY through its adaptor protein, KLHL25 (Kelch-like family member 25), to ubiquitinate and degrade ACLY in cells

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS