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FLASH GENE
Symbol KLHL22 contributors: mct - updated : 03-09-2011
HGNC name kelch-like 22 (Drosophila)
HGNC id 25888
Location 22q11.21      Physical location : 20.795.805 - 20.850.170
Synonym name
  • Drosophila kelch-like gene
  • kelch-like
    • Synonym symbol(s) KELCHL, FLJ14360
    DNA
    TYPE functioning gene
    STRUCTURE 54.36 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2637 - 634 - 2009 19995937
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland    
    Nervousnerve    
    Reproductivefemale systemovary   
     male systemprostate   
    Respiratoryrespiratory tractlarynx   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one BTB(POZ) domain
  • six Kelch repeats
    • HOMOLOGY
    interspecies homolog to murine Klhl22 (94.3pc)
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein KLHL21 and KLHL22, interact with CUL3 and are required for efficient chromosome alignment
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS