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FLASH GENE
Symbol KLHL20 contributors: mct/npt/shn/pgu - updated : 15-03-2016
HGNC name kelch-like 20 (Drosophila)
HGNC id 25056
Location 1q25.1      Physical location : 173.684.079 - 173.755.838
Synonym name
  • Kelch motif containing protein
  • kelch-like ECT2 interacting protein
  • kelch-like ECT2-interacting protein
  • kelch-like protein 20
  • kelch-like protein X
  • Synonym symbol(s) KHLHX, KLEIP, KLHLX, RP3-383J4.3
    DNA
    TYPE functioning gene
    STRUCTURE 71.76 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D1S1165 - D1S2790 - KLHL20 - D1S2814 - D1S1589 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3505 64 609 - PMID: 14668487
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveintestinesmall intestine  moderately
     liver   moderately
    Endocrinepancreas   highly
    Lymphoid/Immunespleen   moderately
     thymus   moderately
    Nervousbrain   moderately
    Reproductivefemale systemplacenta  moderately
     female systemovary  moderately
     male systemtestis  moderately
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a BTB/poxvirus, zinc finger domain (amino acids 53–165)
  • a BTB and C-terminal kelch (BACK) domain (amino acids 170–268)
  • a six-tandem kelch repeats (amino acids 307–609)
  • mono polymer dimer
    HOMOLOGY
    interspecies ortholog to Klhl20, Mus musculus
    ortholog to Klhl20, Rattus norvegicus
    ortholog to klhl20, Danio rerio
    ortholog to KLHL20, Pan troglodytes
    Homologene
    FAMILY
  • kelch family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • concentrated at cell-cell contact
  • is localized to the trans-Golgi network (TGN) and is important for post-Golgi trafficking by promoting the biogenesis of TGN-derived transport carriers
  • basic FUNCTION
  • involved in cytoskeleton organization and biogenesis
  • implicated in Rac1-induced actin organization during cell-cell contact in Madin-Darby canine kidney cells
  • BTB-kelch protein characterized as an actin-binding protein that interacts with the nucleotide exchange factor ECT2
  • may play a critical role in controlling the functions of migrating, proliferating, and invading endothelial cells during angiogenesis
  • in endothelial cells, acts as an essential downstream regulator of VEGF- and basic fibroblast growth factor-induced migration
  • regulator of endothelial function during angiogenesis that controls the VEGF-induced activation of Rho GTPases
  • a negative regulator of Death-associated protein kinase
  • functions as a substrate adaptor bringing DAPK to Cul3 promoting DAPK ubiquitination and proteasomal degradation
  • novel player that regulates EPAS1 protein expression through mechanisms independent of hypoxia and VHL
  • increases the stability of EPAS1 protein independent of the O2-sensitive degradation pathway and consequently activates EPAS1 activity
  • control of KLHL20 expression indirectly inhibits EPAS1 expression
  • actin binding protein that regulates cell-cell contact formation and cell migration
  • is an important molecule regulating corneal epithelial integrity
  • key role of KLHL20 in autophagy termination by controlling autophagy-dependent turnover of ULK1 and VPS34 complex subunits
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • F-actin , tramtrack, bric-a-brac (BTB)/poxvirus, zinc finger (POZ) motif and six-tandem kelch repeats
  • KLHL20-CUL3-RBX1 E3 ligase complex promotes DAPK1 polyubiquitination, thereby inducing the proteasomal degradation of DAPK1, and controling interferon response
  • promoted neurite outgrowth and arborization in hippocampal and cortical neurons through its interaction with CUL3 to form a ubiquitin ligase complex
  • targeting ARHGEF11 to KLHL20 required ARHGEF11 phosphorylation by MAPK14 mitogen-activated protein kinase
  • role of KLHL20-mediated K33-ubiquitination of CORO7 in post-Golgi transport, identifiing a cellular recognition mechanism for this ubiquitin chain type
  • ULK1, a serine/threonine kinase critical for autophagy initiation, is a substrate of the CUL3-KLHL20 ubiquitin ligase
  • cell & other
    REGULATION
    Other KLEIP recruitment to the cell-cell junctions is regulated by E-Cadherin
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to Klhl20, Mus musculus
    ortholog to Klhl20, Rattus norvegicus
    ortholog to klhl20, Danio rerio
    ortholog to KLHL20, Pan troglodytes
    Homologene
    FAMILY kelch family
    CATEGORY
    SUBCELLULAR LOCALIZATION plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • concentrated at cell-cell contact
  • is localized to the trans-Golgi network (TGN) and is important for post-Golgi trafficking by promoting the biogenesis of TGN-derived transport carriers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other KLEIP recruitment to the cell-cell junctions is regulated by E-Cadherin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in Kleip(-/-) mice the initial stratified squamous corneal epithelium was altered to an epidermal histo-architecture showing several superficial keratinized cells, cell infiltrations into the stroma, and several apoptotic cells