basic FUNCTION
| involved in cytoskeleton organization and biogenesis |
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implicated in Rac1-induced actin organization during cell-cell contact in Madin-Darby canine kidney cells |
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BTB-kelch protein characterized as an actin-binding protein that interacts with the nucleotide exchange factor ECT2 |
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may play a critical role in controlling the functions of migrating, proliferating, and invading endothelial cells during angiogenesis |
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in endothelial cells, acts as an essential downstream regulator of VEGF- and basic fibroblast growth factor-induced migration |
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regulator of endothelial function during angiogenesis that controls the VEGF-induced activation of Rho GTPases |
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a negative regulator of Death-associated protein kinase |
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functions as a substrate adaptor bringing DAPK to Cul3 promoting DAPK ubiquitination and proteasomal degradation |
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novel player that regulates EPAS1 protein expression through mechanisms independent of hypoxia and VHL |
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increases the stability of EPAS1 protein independent of the O2-sensitive degradation pathway and consequently activates EPAS1 activity |
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control of KLHL20 expression indirectly inhibits EPAS1 expression |
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actin binding protein that regulates cell-cell contact formation and cell migration |
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is an important molecule regulating corneal epithelial integrity |
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key role of KLHL20 in autophagy termination by controlling autophagy-dependent turnover of ULK1 and VPS34 complex subunits |