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FLASH GENE
Symbol KLHL2 contributors: mct - updated : 19-10-2015
HGNC name kelch-like 2, Mayven (Drosophila)
HGNC id 6353
Location 4q21.2      Physical location : 166.128.769 - 166.244.307
Synonym name
  • kelch (Drosophila)-like 2 (Mayven)
  • actin-binding protein Mayven
  • Synonym symbol(s) ABP-KELCH, MAV, MAYVEN, kelch
    DNA
    TYPE functioning gene
    STRUCTURE 115.00 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif
    MAPPING cloned Y linked   status provisional
    Physical map
    ANP32C 4q32.2 acidic (leucine-rich) nuclear phosphoprotein 32 family, member C LOC389239 4 similar to ring finger protein 129 LOC391709 4 similar to 60S ribosomal protein L26 LOC391710 4 similar to ring finger protein 129 LOC389240 4 similar to alpha NAC/1.9.2. protein LOC391711 4 similar to ring finger protein 129 FLJ31659 4q32.3 hypothetical protein FLJ31659 LOC391712 4 similar to ring finger protein 129 LOC391713 4 similar to ring finger protein 129 RNF129 4q32.3 ring finger protein 129 LOC391714 4 similar to ring finger protein 129 FLJ38482 4q32.3 hypothetical protein FLJ38482 KLHL2 4q21.2 kelch-like 2, Mayven (Drosophila) GKP3 4q32.1 glycerol kinase pseudogene 3 SC4MOL 4q32-q34 sterol-C4-methyl oxidase-like CPE 4q31 carboxypeptidase E HADHAP 4q32 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase pseudogene (gastrin binding protein pseudogene) LOC285507 4q32.3 similar to chromosome 9 open reading frame 34 LOC391715 4 similar to RING finger protein 15 (Zinc finger protein RoRet) (Tripartite motif-containing protein 38) TLL1 4q32-q33 tolloid-like 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3159 65.9 593 - Bu (2005)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Endocrinethyroid   highly
    Nervousbrain   predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal unique domain homolog to Drosophila oocyte maturation ring canal, BTB/POZ domain
  • the poxvirus zinc finger protein, protein interaction domain
  • C terminal Kelch repeat domains consisting of six tandemly arranged repeats
  • HOMOLOGY
    interspecies homolog to Drosophila Kelch -like 2 5termed Mayven°
    Homologene
    FAMILY
  • kelch-related superfamily of proteins
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • that may be translocated along axonal processes and might be involved in the dynamic organization of the actin cytoskeleton in brain cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin-binding
  • KLHL2 interacts with and ubiquitinates WNK1 and WNK4 kinases
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    may promote tumor growth through c-Jun and cyclin D1, in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS