basic FUNCTION
| may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis |
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negatively regulating the Wnt-beta-catenin pathway by targeting Dishevelled for degradation |
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functions as an adaptor between the D4 receptor and CUL3, and targets the D4 receptor to the E3 ligase complex by a direct and simultaneous interaction with the D4 receptor (DRD4) and CUL3, which gives rise to ubiquitination of the D4 receptor (DRD4) |
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KLHL12 is a novel interaction partner of the DRD4 that functions as an adaptor in a CUL3-based E3 ubiquitin ligase complex to target the receptor for ubiquitination |
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CUL3-KLHL12 catalyses the monoubiquitylation of the COPII-component SEC31 and drives the assembly of large COPII coats |
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ubiquitylation by CUL3-KLHL12 is essential for collagen export, yet less important for the transport of small cargo |
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KLHL12 plays a critical role in facilitating the ER exit and secretion of APOB100-VLDL particles, suggesting that KLHL12 modulation would influence plasma lipid levels |