Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol KLHL1 contributors: - updated : 02-10-2007
HGNC name kelch-like 1 (Drosophila)
HGNC id 6352
Location 13q21      Physical location : 70.274.725 - 70.682.625
Synonym name
  • Mayven-related protein 2
  • Synonym symbol(s) KIAA1490, MRP2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE overlapping, gene in gene, opposite orientation
    text opposite orientation with the antisense SCA8
    STRUCTURE 407.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC144762 13q21.1 hypothetical LOC144762 LOC390408 13 similar to sequestosome 1; oxidative stress induced LOC338861 13q21.2 similar to protein phosphatase 1, regulatory (inhibitor) subunit 2 FLJ25694 13q21.2 hypothetical protein FLJ25694 LGMN2P 13q21.2 legumain 2 pseudogene STARP1 13pter-13qter steroidogenic acute regulatory protein pseudogene 1 LOC387933 13 similar to heterogeneous nuclear ribonucleoprotein A3 PCDH9 13q13.3 protocadherin 9 LOC390410 13 similar to 40S RIBOSOMAL PROTEIN SA (P40) (34/67 KD LAMININ RECEPTOR) LOC390411 13 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 OR7E33P 13q22.3 olfactory receptor, family 7, subfamily E, member 33 pseudogene LOC390412 13 hypothetical gene supported by BC050367 KLHL1 13q21 kelch-like 1 (Drosophila) DACH 13q21-q22 dachshund homolog (Drosophila) FLJ22624 13q21.33 FLJ22624 protein DIS3 13q21.33 FLJ22624 protein PIBF1 13q21.33 progesterone-induced blocking factor 1 LOC338091 13q21 proteasome 26S non-ATPase subunit 10 pseudogene KLF5 13q21.33 Kruppel-like factor 5 (intestinal) LOC387934 13 similar to Fatty acid-binding protein, epidermal (E-FABP) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP) LOC122134 13q21.33 similar to MAP/microtubule affinity-regulating kinase 3 LOC387935 13 LOC387935 KLF12 13q22 Kruppel-like factor 12 LOC122145 13q21.33 suppressor of bimD6 homolog pseudogene LOC387936 13 hypothetical gene supported by AL133018 LOC387937 13 LOC387937 TBC1D4 13q22 TBC1 domain family, member 4 AK000009  Acrg embryonic lethality (mouse) minimal region ortholog UCHL3 13q22 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) LMO7 13q22 LIM domain only 7 KCTD12 13q21 potassium channel tetramerisation domain containing 12 BTF3L1 13q22 basic transcription factor 3, like 1 LOC341720 13q22.1 similar to immune-responsive gene 1 LOC390413 13 similar to 60S ribosomal protein L7 DHX9P 13q21 DEAH (Asp-Glu-Ala-His) box polypeptide 9 pseudogene CLN5 13q22 ceroid-lipofuscinosis, neuronal 5 FBXL3A 13q22 F-box and leucine-rich repeat protein 3A
    RNA
    TRANSCRIPTS type messenger
    text mRNAs produced by alternative splicing (Nemes, 2000)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Nervousbrainbasal nuclei  highly
     brainhindbraincerebellum  
    Reproductivefemale systemuteruscervix predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a BTB/POZ domain
  • six KELCH repeats
  • HOMOLOGY
    interspecies homolog to dog KLHL1 (98.2 pc)
    homolog to chimpanzee KLHL1 (99.3 pc)
    homolog to rattus Klhl1 (95.3 pc)
    homolog to murine Klhl1 (95.6 pc)
    Homologene
    FAMILY
  • evolutionarily-conserved Kelch protein super-family
  • actin-organizing protein family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • playing a role in the organization of the actin cytoskeleton of the brain cells
  • playing a possible novel role in cellular excitability
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to actin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS