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FLASH GENE
Symbol KLHL1 contributors: - updated : 02-10-2007
HGNC name kelch-like 1 (Drosophila)
HGNC id 6352
Location 13q21      Physical location : 70.274.725 - 70.682.625
Synonym name
  • Mayven-related protein 2
  • Synonym symbol(s) KIAA1490, MRP2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE overlapping, gene in gene, opposite orientation
    text opposite orientation with the antisense SCA8
    STRUCTURE 407.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    text mRNAs produced by alternative splicing (Nemes, 2000)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Nervousbrainbasal nuclei  highly
     brainhindbraincerebellum  
    Reproductivefemale systemuteruscervix predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a BTB/POZ domain
  • six KELCH repeats
  • HOMOLOGY
    interspecies homolog to dog KLHL1 (98.2 pc)
    homolog to chimpanzee KLHL1 (99.3 pc)
    homolog to rattus Klhl1 (95.3 pc)
    homolog to murine Klhl1 (95.6 pc)
    Homologene
    FAMILY
  • evolutionarily-conserved Kelch protein super-family
  • actin-organizing protein family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • playing a role in the organization of the actin cytoskeleton of the brain cells
  • playing a possible novel role in cellular excitability
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to actin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS