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FLASH GENE
Symbol KLHDC10 contributors: mct - updated : 21-10-2014
HGNC name kelch domain containing 10
HGNC id 22194
Location 7q32.2      Physical location : 129.710.348 - 129.775.559
Synonym name
  • similar to slime mold actin-fragmin kinase
  • hypothetical protein LOC23008
  • scruin like at the midline homolog (Drosophila)
  • PNAS-119
  • Synonym symbol(s) KIAA0265, slim
    DNA
    TYPE functioning gene
    STRUCTURE 65.17 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4488 - 442 - 2003 12853948
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineparathyroid   highly
    Hearing/Equilibriumearinnercochlea highly
    Lymphoid/Immunelymph node    
    Nervousnerve   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to Slim
    ortholog to murine 2410127E18Rik
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • KLHDC10 is likely a cell-type specific regulator of necroptosis that ultimately contributes to the development of TNF-induced Systemic inflammatory response syndrome (SIRS)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KLHDC10 bound to the phosphatase domain of PPP5C and suppressed its phosphatase activity
  • is an activator of MAP3K5, contributing to oxidative stress-induced cell death through the suppression of PPP5C
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • KLHDC10-deficient mice show a reduction in the inflammatory response, but not in early systemic necroptosis