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FLASH GENE
Symbol KLF7 contributors: mct - updated : 18-02-2017
HGNC name Kruppel-like factor 7 (ubiquitous)
HGNC id 6350
Location 2q33.3      Physical location : 207.945.528 - 208.030.614
Synonym name
  • ubiquitous Kruppel-like factor
  • ubiquitous Kruppel-like transcription factor
  • Synonym symbol(s) UKLF
    DNA
    TYPE functioning gene
    STRUCTURE 99.71 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D2S355 - KLF7 - CPS1 - ACADL ACADL - MAP2 - ERBB4 - D2S371 - D2S317 - D2S143 - FN1 - D2S137 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 8433 33.4 302 - 1998 9774444
    4 - 7990 - 269 - 1998 9774444
    5 - 8021 - 230 - 1998 9774444
    - - 7954 - 274 - 1998 9774444
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly Homo sapiens
     spinal cord     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text
  • restricted within the nervous system during development
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal, acidic Glu-rich region, reducing neuronal expression, but also appear to be required for transcriptional activation and promotion of neurite outgrowth
  • a highly conserved 81 AA DNA binding domain
  • a serine-rich hydrophobic region
  • a C terminal portion containing three zinc fingers of the C2-H2 type Krüppel-like
  • HOMOLOGY
    interspecies ortholog to murine Klf7
    homolog to Drosophila CG12029
    homolog to C.elegans F56F11.3
    intraspecies homolog to core promoter element binding protein (COPEB)
    Homologene
    FAMILY
  • CACCC binding zinc finger family
  • Krüppel family of C2H2-type zinc-finger proteins
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • can function as a transcription activator
  • control neuronal morphogenesis in part by optimizing the levels of molecules that promote axon outgrowth
  • may contribute to the pathogenesis of type 2 diabetes through an impairment of insulin biosynthesis and secretion in pancreatic beta-cells and a reduction of insulin sensitivity in peripheral tissues
  • with POU4F1 are each required for efficient transcription of NTRK1 in primary sensory neurons, and cooperation between these two transcription factors is required for endogenous NTRK1 gene expression and the survival of nociceptive sensory neurons
  • plays a critical role in neurite outgrowth and neuronal survival
  • regulates the expression of genes involved in the maturation and function of olfactory sensory neurons
  • role in neuronal development, particularly of retinal ganglion and sensory neurons
  • has a broad spectrum of regulatory functions, which reflect the discrete cellular and molecular contexts in which this transcription factor operates
  • required for neuronal morphogenesis and axon guidance in selected regions of the nervous system, including hippocampus, olfactory bulbs and cortex
  • its expression correlates with regenerative capacity across neuronal age, species, and cellular subtype, and is important both for the development of cortical efferent axons in mammals
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcriptional activator
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding CACCC box containing proteins
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binding sites for GAP43, STMN2, OMP and ADCY3 promoters
  • interacting with NTRK2 (a KLF7-binding element conserved in mouse and human TRKB promoters is required for CREB1-dependent transcription)
  • KLF7/VPS35 axis contributes to hepatocellular carcinoma progression through CCDC85C-activated CTNNB1 pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    useful target for new drugs to aid in the prevention and treatment of type 2 diabetes
    neurologyacquired 
    represents a powerful and potentially therapeutically relevant means by which to promote regenerative capacity in adult CNS neurons
    ANIMAL & CELL MODELS
    significant alterations in dopaminergic neurons in Klf7 null mice