basic FUNCTION
| can function as a transcription activator |
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control neuronal morphogenesis in part by optimizing the levels of molecules that promote axon outgrowth |
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may contribute to the pathogenesis of type 2 diabetes through an impairment of insulin biosynthesis and secretion in pancreatic beta-cells and a reduction of insulin sensitivity in peripheral tissues |
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with POU4F1 are each required for efficient transcription of NTRK1 in primary sensory neurons, and cooperation between these two transcription factors is required for endogenous NTRK1 gene expression and the survival of nociceptive sensory neurons |
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plays a critical role in neurite outgrowth and neuronal survival |
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regulates the expression of genes involved in the maturation and function of olfactory sensory neurons |
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role in neuronal development, particularly of retinal ganglion and sensory neurons |
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has a broad spectrum of regulatory functions, which reflect the discrete cellular and molecular contexts in which this transcription factor operates |
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required for neuronal morphogenesis and axon guidance in selected regions of the nervous system, including hippocampus, olfactory bulbs and cortex |
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its expression correlates with regenerative capacity across neuronal age, species, and cellular subtype, and is important both for the development of cortical efferent axons in mammals |