basic FUNCTION
| putatively involved in programming the quiescent state of single positive T cells and in maintaining their viability in the peripheral lymphoid organs and blood |
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blood wall morphogenesis |
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transcriptional silencer |
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acting as a negative regulator of monocytic activation |
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differentially regulating key factors involved in maintaining an antithrombotic endothelial surface, and transcriptional regulator of endothelial thrombotic function |
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may act as a novel immediate-early transcriptional factor to maximally prime T cell activation |
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plays a role in the maturation and/or stability of erythroid cells in the yolk sac, and is essential for primitive erythropoiesis and regulates the embryonic beta-like globin genes |
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in T cells, KLF2 controls the exit of thymocytes into the blood by regulating the expression of the chemoattractant receptor S1Pr1 |
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plays an important role in differentiation and function in a variety of cell types, including T lymphocytes, monocytes, lung cells, and adipocytes |
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plays crucial and unique roles in the vascular wall by functioning as an important transcriptional integrator of upstream and downstream signaling necessary for blood vessel formation |
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inhibitor of HIF1A expression and function, disrupting the interaction between HIF1A and HSP90 |
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critical for normal trafficking of T lymphocytes |
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plays a critical role in dictating normal subset differentiation and functional reactivity of mature B cells |
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critical for normal B-cell tissue localization, subset differentiation, and functional reactivity |
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s crucial for B-cell subset differentiation as well as regulation of B-cell activation and trafficking |
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controls homeostasis of mature B cell subsets in peripheral lymphatic organs and homing of antibody-secreting plasma cells to the bone marrow, presumably by controlling the expression of the adhesion molecule beta7-integrin |
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KLF1 and KLF2 positively regulate the embryonic and fetal beta-globin genes through direct promoter binding |
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distinct yet overlapping mechanistic roles for KLF1 and KLF2 in embryonic red blood cells |
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role for myeloid KLF2 expression in modulating atherosclerosis |
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KLF1, KLF2, and MYC control a regulatory network essential for embryonic erythropoiesis |
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is implicated as a key molecule maintaining endothelial function |
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KLF2 and NFE2L2 are major transcriptional factors that contribute to anti-atherogenic responses under laminar flow |
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link between KLF2-induced hepatic triglyceride accumulation and the expression of CD36 |
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is an essential factor that sustains ground state pluripotency |
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KLF1 and KLF2 coordinately regulate embryonic erythroid precursor maturation through the regulation of multiple homeostasis-associated genes |
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is involved in strict repression of TERT expression through binding to the promoter in primary human T cells |
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suppressive functions of KLF2 in pancreatic ductal adenocarcinoma |
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continuous role of KLF2 in stabilizing the vessel wall via co-temporal expression of eNOS and AQP1 both preceding and during the pathogenesis of atherosclerosis |