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FLASH GENE
Symbol KLF16 contributors: - updated : 08-06-2005
HGNC name Kruppel-like factor 16
HGNC id 16857
Location 19p13.3      Physical location : 1.852.398 - 1.863.564
Synonym name basic transcription element binding protein 4
Synonym symbol(s) DRRF, BTEB4, NSLP2
DNA
TYPE functioning gene
STRUCTURE 11.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonhypothalamusnucleus accumbens 
 brainbasal nucleistriatum  
 brainforebraincerebral cortexfrontal 
Olfactoryolfactory bulb    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a proline and alanine rich domain
  • three zinc finger motifs of the C2H2 type forming a DNA binding domain
    • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to Drosophila EP2237
    ortholog to murine Klf16
    intraspecies homolog to BTEB1
    Homologene
    FAMILY Sp1-like family of GC box binding transcription factors
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a modulator of dopamine receptor through binding to DR promoters
  • repressing CYP1A1 gene promoter via the BTE site
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    modulating dopaminergic transmission in brain
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein binding to SIN3A
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS