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FLASH GENE
Symbol KLF14 contributors: mct/ - updated : 28-03-2012
HGNC name Kruppel-like factor 14
HGNC id 23025
Location 7q32.3      Physical location : 130.417.396 - 130.418.888
Synonym name
  • basic transcription elemnt-binding protein 5
  • transcription factor BTEB5
  • BTE-binding protein 5
  • Synonym symbol(s) BTEB5
    DNA
    TYPE functioning gene
    STRUCTURE 1.49 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA1170 7q32.3 KIAA1170 protein NRF1 7q32 nuclear respiratory factor 1 UBE2H 7q32 ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) NIPA 7q32.3 nuclear interacting partner of anaplastic lymphoma kinase (ALK) KIAA0265 7q32.3 KIAA0265 protein LOC389556 7 LOC389556 FLJ14803 7q32.3 hypothetical protein FLJ14803 LOC136263 7q32.3 LOC136263 CPA2 7q32 carboxypeptidase A2 (pancreatic) CPA4 7q32 carboxypeptidase A4 CPA5 7q32 carboxypeptidase A5 CPA1 7q32 carboxypeptidase A1 (pancreatic) TSGA14 7q32 testis specific, 14 MEST 7q32 mesoderm specific transcript homolog (mouse) COPG2 7q32 coatomer protein complex, subunit gamma 2 TSGA13 7q32 testis specific, 13 KLF14 7q32.3 Kruppel-like factor 14 LOC347674 7q32 ALEX2 pseudogene LOC340349 7q32.3 hypothetical LOC340349 FLJ43663 7q32.3 hypothetical protein FLJ43663 LOC136256 7q32.3 similar to ribosomal protein L27 MKLN1 7q32 muskelin 1, intracellular mediator containing kelch motifs PODXL 7q32-q33 podocalyxin-like LOC389557 7 hypothetical gene supported by BC029316; NM_021121
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1509 - 323 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three C2H2-type zinc fingers
  • a highly conserved 81 AA DNA binding domain
  • HOMOLOGY
    Homologene
    FAMILY
  • Sp1 C2H2-type zinc finger protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may have a role in the regulation of transcription
  • imprinted transcript undergoing accelerated evolution in the human lineage
  • TGFbeta-inducible, non-Smad protein that silences the TGFbeta receptor II (TGFBR2) promoter
  • acts as a master trans regulator of adipose gene expression
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+ binding
    protein
  • represses the TGFBR2, a function that is augmented by TGFbeta treatment
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to type 2 diabetes
  • Variant & Polymorphism SNP
  • increasing the risk of type 2 diabetes
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Epfn mutant mice have a defective autopod that shows mesoaxial syndactyly in the forelimb and synostosis (bony fusion) in the hindlimb and partial bidorsal digital tips