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FLASH GENE
Symbol KLF14 contributors: mct/ - updated : 28-03-2012
HGNC name Kruppel-like factor 14
HGNC id 23025
Location 7q32.3      Physical location : 130.417.396 - 130.418.888
Synonym name
  • basic transcription elemnt-binding protein 5
  • transcription factor BTEB5
  • BTE-binding protein 5
  • Synonym symbol(s) BTEB5
    DNA
    TYPE functioning gene
    STRUCTURE 1.49 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1509 - 323 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three C2H2-type zinc fingers
  • a highly conserved 81 AA DNA binding domain
  • HOMOLOGY
    Homologene
    FAMILY
  • Sp1 C2H2-type zinc finger protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may have a role in the regulation of transcription
  • imprinted transcript undergoing accelerated evolution in the human lineage
  • TGFbeta-inducible, non-Smad protein that silences the TGFbeta receptor II (TGFBR2) promoter
  • acts as a master trans regulator of adipose gene expression
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+ binding
    protein
  • represses the TGFBR2, a function that is augmented by TGFbeta treatment
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to type 2 diabetes
  • Variant & Polymorphism SNP
  • increasing the risk of type 2 diabetes
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Epfn mutant mice have a defective autopod that shows mesoaxial syndactyly in the forelimb and synostosis (bony fusion) in the hindlimb and partial bidorsal digital tips