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FLASH GENE
Symbol KLF13 contributors: mct/ - updated : 09-03-2015
HGNC name Kruppel-like factor 13
HGNC id 13672
Location 15q13.3      Physical location : 31.619.082 - 31.670.101
Synonym name
  • rantes factor of late-activated T-lymphocytes 1
  • basic transcription element binding protein 3
  • novel Sp1-like zinc finger transcription factor 1
  • BTE-binding protein 3
  • Synonym symbol(s) NSLP1, RFLAT1, FKLF2, BTEB3, RFLAT-1
    DNA
    TYPE functioning gene
    STRUCTURE 51.02 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure promoter was trans-activated by co-expressed GATA-1 through the sequence containing two CCAAT motifs, suggesting that GATA-1 is involved in the abundant expression of KLF13 mRNA in the erythroid tissue
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390557 15 similar to chromosome condensation protein G LOC283698 15q13.1 similar to synaptogyrin 2; cellugyrin LOC283717 15q13.1 similar to hypothetical protein FLJ35785 LOC390558 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC388097 15 similar to hyperpolarization activated cyclic nucleotide-gated potassium channel 2; brain cyclic nucleotide gated channel 2 CHRFAM7A 15q13-q14 CHRNA7 (cholinergic receptor, nicotinic, alpha polypeptide 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion LOC390559 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC388098 15 similar to hypothetical protein FLJ35785 LOC388099 15 similar to M-phase phosphoprotein 10 LOC342167 15q13.1 similar to hypothetical protein FLJ35785 LOC390560 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC388100 15 hypothetical gene supported by AF029838; NM_139320 LOC388101 15 hypothetical gene supported by NM_173613 LOC388102 15 hypothetical gene supported by NM_014783 LOC390561 15 similar to hypothetical protein FLJ35785 LOC388103 15 hypothetical gene supported by NM_004667 LOC388104 15 similar to chromosome 1 open reading frame 37 KIAA1018 15q12 similar to chromosome 1 open reading frame 37 FLJ20313 15q13.1 hypothetical protein FLJ20313 TRPM1 15q13-q14 transient receptor potential cation channel, subfamily M, member 1 LOC283710 15q13.1 hypothetical LOC283710 KLF13 15q13.3-q14 Kruppel-like factor 13 LOC283711 15q13.1 hypothetical protein LOC283711 LOC388105 15 hypothetical gene supported by BC009274; NM_020385 C15orf16 15q13.1 chromosome 15 open reading frame 16 LOC388106 15 hypothetical gene supported by BC035506; BC041580; NM_017779 CHRNA7 15q14 cholinergic receptor, nicotinic, alpha polypeptide 7 LOC388107 15 similar to hyperpolarization activated cyclic nucleotide-gated potassium channel 2; brain cyclic nucleotide gated channel 2 LOC390562 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC161719 15q13.2 similar to hypothetical protein FLJ35785 LOC388108 15 similar to FLJ20574 protein LOC390563 15 similar to golgin-67 isoform c LOC390564 15 similar to neuronal nicotinic acetylcholine receptor beta4 subunit LOC338978 15q13.2 similar to M-phase phosphoprotein 10 LOC283719 15q13.2 similar to KIAA1971 protein LOC388109 15 similar to hypothetical protein FLJ35785 ARHGAP11A 15q13.2 similar to human GTPase-activating protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 6817 - 288 - 2005 15716005
    1 - 1241 - 280 - 2005 15716005
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Cardiovascularheart   predominantly
    Digestiveliver   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythroid
    Blood/Hematopoieticleukocyte
    Lymphoid/Immunelymphocyte
    cell lineage erythroid cell lines, highly
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative transactivation domain rich in proline and alanine at the N terminus (3PXXP motifs) associating with SH3 domain of tyrosine kinases
  • a highly conserved 81 AA DNA binding domain
  • a repression domain
  • a nuclear localization signal (NLS)
  • three Sp1-like zinc finger motifs at the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • Sp1 C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • activation of globin genes, predominantly gamma and a wide range of genes in cells of erythroid lineage
  • important component of the transcription network required for heart development
  • is involved in the normal control of erythropoiesis
  • involved in the development of B and T cells at multiple stages
  • involved at multiple different checkpoints in development that require signalling through the TCR, pre-BCR or mature BCR
  • key role for KLF13 in the expression of IL-4 in CD4(+) T cells
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • repressing CYP1A1 gene promoter via the BTE site
  • KLF13 binds proximal LDLR DNA sequences and exogenous oxysterol up-regulates such binding
  • binding the CTCB box and activating RANTES (CCL5)
  • interaction with GATA4, a dosage-sensitive cardiac regulator (may be GATA4 modifier)
  • controls the late (3-5 days after activation) expression of CCL5 in T lymphocytes and that KLF13 itself is translationally regulated through the 5prime -untranslated region of its mRNA
  • key role for KLF13 in the expression of IL4 in CD4(+) T cells
  • KLF13 cooperates with MAF to regulate IL4 expression in CD4+ T cells
  • cell & other
    REGULATION
    Other activated after T cell activation with other genes and allowing T cells to rapidly adjust CCL5 expression in response to changes in cellular environment stress or growth factors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    may be causative for congenital heart disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • viable Klf13(-/-) mice had reduced numbers of circulating erythrocytes and a larger spleen
  • in murine T lymphocytes, Klf13 protein is abundant because of the absence of Fbxw7