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FLASH GENE
Symbol KLF13 contributors: mct/ - updated : 09-03-2018
HGNC name Kruppel-like factor 13
HGNC id 13672
Location 15q13.3      Physical location : 31.619.082 - 31.670.101
Synonym name
  • rantes factor of late-activated T-lymphocytes 1
  • basic transcription element binding protein 3
  • novel Sp1-like zinc finger transcription factor 1
  • BTE-binding protein 3
    • Synonym symbol(s) NSLP1, RFLAT1, FKLF2, BTEB3, RFLAT-1
    DNA
    TYPE functioning gene
    STRUCTURE 51.02 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure promoter was trans-activated by co-expressed GATA-1 through the sequence containing two CCAAT motifs, suggesting that GATA-1 is involved in the abundant expression of KLF13 mRNA in the erythroid tissue
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 6817 - 288 - 2005 15716005
    1 - 1241 - 280 - 2005 15716005
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Cardiovascularheart   predominantly
    Digestiveliver   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythroid
    Blood/Hematopoieticleukocyte
    Lymphoid/Immunelymphocyte
    cell lineage erythroid cell lines, highly
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative transactivation domain rich in proline and alanine at the N terminus (3PXXP motifs) associating with SH3 domain of tyrosine kinases
  • a highly conserved 81 AA DNA binding domain
  • a repression domain
  • a nuclear localization signal (NLS)
  • three Sp1-like zinc finger motifs at the C terminus
    • HOMOLOGY
    Homologene
    FAMILY
  • Sp1 C2H2-type zinc-finger protein family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • activation of globin genes, predominantly gamma and a wide range of genes in cells of erythroid lineage
  • important component of the transcription network required for heart development
  • is involved in the normal control of erythropoiesis
  • involved in the development of B and T cells at multiple stages
  • involved at multiple different checkpoints in development that require signalling through the TCR, pre-BCR or mature BCR
  • key role for KLF13 in the expression of IL-4 in CD4(+) T cells
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • repressing CYP1A1 gene promoter via the BTE site
  • KLF13 binds proximal LDLR DNA sequences and exogenous oxysterol up-regulates such binding
  • binding the CTCB box and activating RANTES (CCL5)
  • interaction with GATA4, a dosage-sensitive cardiac regulator (may be GATA4 modifier)
  • controls the late (3-5 days after activation) expression of CCL5 in T lymphocytes and that KLF13 itself is translationally regulated through the 5prime -untranslated region of its mRNA
  • key role for KLF13 in the expression of IL4 in CD4(+) T cells
  • KLF13 cooperates with MAF to regulate IL4 expression in CD4+ T cells
  • ACOT7 is transcriptionally activated by KLF13 and promotes the progression of hepatocellular carcinoma
    • cell & other
    REGULATION
    Other activated after T cell activation with other genes and allowing T cells to rapidly adjust CCL5 expression in response to changes in cellular environment stress or growth factors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    may be causative for congenital heart disease
    tumoral     --over  
    in Hepatocellular carcinoma (HCC) tissues and facilitated HCC progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • viable Klf13(-/-) mice had reduced numbers of circulating erythrocytes and a larger spleen
  • in murine T lymphocytes, Klf13 protein is abundant because of the absence of Fbxw7