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FLASH GENE
Symbol KLF12 contributors: - updated : 08-06-2005
HGNC name Kruppel-like factor 12
HGNC id 6346
Location 13q22      Physical location : 74.260.149 - 74.708.066
Synonym name
  • AP-2 repressor
  • AP-2rep transcription factor
  • Synonym symbol(s) AP2REP, HSPC122
    DNA
    TYPE functioning gene
    STRUCTURE 321.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 10891 44.3 4029 - Imhof
    - splicing 1597 29.6 269 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     spleen   highly
    Nervousbrain    
    Urinarykidney    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three Gli-Krüppel C2H2 type zinc finger at the C terminus
  • a highly conserved 81 AA DNA binding domain
  • a H/C knuckle, a serine/threonine rich domain
  • a PVDLS motif contacting C terminal binding proteins
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY CACCC binding zinc finger family,C2H2 type zinc finger protein
    CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION transcriptional silencer to the AP2-alpha gene, mediating positive and negative regulation of the AP2-A expression trhough a set of overlapping cis-regulatory promoters elements
    CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text regulation of development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA bindingto O-regulatory element (A32) in the AP-2 alpha gene promoter
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein interacting with CTBP1 for corepression of AP2A1 complex
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS