basic FUNCTION
| acting as a glucosidase |
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plays a critical role in the regulation of calcium and phosphorus homeostasis by negatively regulating active vitamin D synthesis |
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plays a protective role against lipotoxicity and inflammation in hepatocytes |
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required for FGF19 binding to FGFR4, intracellular signaling, and downstream modulation of gene expression |
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required for FGF21 to activate two specific FGFR subtypes: FGFR1c and FGFR3c |
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regulating FGF21 (its expression is a crucial determinant of the FGF21 specificity of the target cells upon which it acts in an endocrine fashion) |
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may play a central role by binding to and recruiting FGF21 to FGFR to induce activation |
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key regulator of bile acid/cholesterol metabolism |
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indispensible role in FGF21-induced ERK1/2 activation, GLUT1 gene transactivation, and glucose uptake in adipocytes |
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suppresses tumor growth in hepatocellular carcinom |
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link of ER stress with up-regulation of hepatic KLB expression and the molecular mechanism underlying ER stress-regulated FGF21 signaling |
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pro-adipogenic role for KLB in skeletal muscle fibro/adipogenesis |
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inhibits epithelial& |
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8209;mesenchymal transition (EMT) and plays a tumor& |
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8209;suppressive role in PCa, linking FGF/FGFR/KLB signaling to the regulation of Prostate cancer (PCa) progression |
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is a gatekeeper of hepatic integrity through direct action (mediating FGF21 anti-inflammatory signaling) and indirect mechanisms (mediating FGF19 signaling that maintains bile acid (BA) level and composition) |