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FLASH GENE
Symbol KIZ contributors: mct - updated : 18-04-2014
HGNC name kizuna centrosomal protein
HGNC id 15865
Corresponding disease
CORD24 retinal cone-rod dystrophy 24
Location 20p11.23      Physical location : -
Synonym name
  • uncharacterized hypothalamus protein HT013
  • chromosome 20 open reading frame 19
  • hypothetical protein LOC55857
  • non-protein coding RNA 153
  • Synonym symbol(s) HT013, DKFZP586H021, C20orf19, DKFZP586H021, MGC102941, MGC141930, Kizuna, PLK1S1 NCRNA00153, PLK1S1
    DNA
    TYPE functioning gene
    STRUCTURE 120.61 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2329 75 673 - -
    12 - 2166 - 570 - -
    11 - 2076 - 540 - -
    11 - 2103 - 624 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyeretina  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningretinal pigment epithelium (RPE) highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificfibroblast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • localization at the basal body of the cilia
  • during mitosis, KIZ localizes to mature centrioles and interacts with PLK1 in order to protect the centrosome from collapsing during spindle formation
  • basic FUNCTION
  • plays a critical role during cell-cycle progression while it undergoes sequential phosphorylation
  • role for KIZ in photoreceptor homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein centrosomal substrate for PLK1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CORD24
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS