Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

KIZ

contributors: mct - updated : 22-12-2020

HGNC name	kizuna centrosomal protein
HGNC id	15865

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CORD24 retinal cone-rod dystrophy 24
Location	20p11.23      Physical location : -
Synonym name	uncharacterized hypothalamus protein HT013
	chromosome 20 open reading frame 19
	hypothetical protein LOC55857
	non-protein coding RNA 153
	polo-like kinase 1 substrate 1
Synonym symbol(s)	HT013, DKFZP586H021, C20orf19, DKFZP586H021, MGC102941, MGC141930, Kizuna, PLK1S1 NCRNA00153

DNA

TYPE	functioning gene
STRUCTURE	120.65 kb     13 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001352436 14 - 2146 NP_001339365 - 559 - 2014 25558830 NM_018474 13 - 2329 NP_060944 75 673 - 2014 25558830 NM_001163022 12 - 1939 NP_001156494 - 570 - 2014 25558830 NM_001276389 11 - 1997 NP_001263318 - 624 - 2014 25558830 NM_001352434 13 - 2048 NP_001339363 - 655 - 2014 25558830 NM_001352435 12 - 1885 NP_001339364 - 552 - 2014 25558830 NM_001163023 11 - 1849 NP_001156495 - 540 - 2014 25558830

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Visual eye retina     highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining retinal pigment epithelium (RPE)   highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol not specific fibroblast Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

HOMOLOGY

interspecies

ortholog to murine Plk1s1

Homologene

FAMILY

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
text	localization at the basal body of the cilia
	during mitosis, KIZ localizes to mature centrioles and interacts with PLK1 in order to protect the centrosome from collapsing during spindle formation

basic FUNCTION	plays a critical role during cell-cycle progression while it undergoes sequential phosphorylation
	KIZ is critical for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation
	role for KIZ in photoreceptor homeostasis
	is a novel mitotic substrate of CDC25B phosphatase that plays a key role in mitosis control

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	CEP72 is essential for the localization of AKAP9 and KIZ
	CEP72 is a Kizuna-interacting protein
	centrosomal substrate for PLK1
	in mitosis KIZ is a new substrate of CDC25B whose dephosphorylation following CDC25B stabilization leads to the formation of multipolar spindles

cell & other

REGULATION

Phosphorylated by

PLK1 (PLK1 likely maintains the integrity of the spindle poles by phosphorylating KIZ)

Other

KIZ phosphorylation depends on a balance between CDC25B and PLK1 activities

ASSOCIATED DISORDERS

corresponding disease(s)

CORD24

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS