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FLASH GENE
Symbol KIR3DL3 contributors: mct - updated : 23-03-2013
HGNC name killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
HGNC id 16312
Location 19q13.42      Physical location : 55.235.983 - 55.248.003
Synonym name
  • killer cell Ig-like receptor KIR3DL7
  • Synonym symbol(s) KIR44, KIRC1, KIR3DL7, CD158Z
    DNA
    TYPE functioning gene
    STRUCTURE 12.01 kb     8 Exon(s)
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure
  • activating element was found in the KIR3DL3 promoter
  • transcription factor binding sites identified a functional acute myeloid leukemia (AML) site common to all three KIR promoters
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1691 - 410 - 2006 16391939
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunenatural killer
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three immunoglobulin-like C2-type domains
  • an N-terminal signal sequence,
  • a transmembrane region lacking a positively charged residue
  • a long cytoplasmic tail containing an immunoreceptor tyrosine-based inhibitory motif (ITIM)
  • a KIR3DL interaction site seem to be largely conserved across the KIR3D family, with specificity differences mapping to a hotspot within the interaction interface
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type i membrane protein
    basic FUNCTION
  • not expressed in healthy individuals, but its expression might be induced under certain developmental or pathological situations
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component natural killer cell receptors cluster FLNKR@
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by RUNX3, (RUNX3 acting as a repressor of KIR expression in mature NK cells)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS