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FLASH GENE
Symbol KIR2DL4 contributors: mct - updated : 30-08-2010
HGNC name killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
HGNC id 6332
Location 19q13.42      Physical location : 57.208 - 55.325.971
Synonym name
  • natural killer cell immunoglobulin-like inhibitory receptor for HLA-G antigen, 2DL4
  • CD158 antigen-like family member D
  • killer cell inhibitory receptor 103AS
  • MHC class I NK cell receptor KIR103AS
  • Synonym symbol(s) 103AS, 15.212, CD158D, KIR103, KIR103AS, G9P
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text natural killer cell receptor cluster FLNKR@
    STRUCTURE 10.91 kb     8 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 1505 37.3 342 - Selvakumar (1997)
    also called AS
    8 - 1609 - 273 - -
    8 splicing 1338 34.1 310 - Selvakumar (1997)
    also called ASD2
    8 splicing 1610 41.5 377 - Selvakumar (1997)
    also called LP
    6 splicing 1158 26.5 245 - Selvakumar (1997)
    also called AST
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte
    Lymphoid/Immunenatural killer
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 24-amino acid leader sequence
  • a 218-amino acid extracellular domain containing 2 putative immunoglobulin-like C2-type domains
  • a 20-amino acid transmembrane domain
  • a 114-residue cytoplasmic tail
  • one immunoreceptor tyrosine based inhibitory motif (ITIM)
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • inhibiting the activity of NK cells thus preventing cell lysis or activating the cytotoxicity of NK cells
  • can stimulate potent cytokine production and weak cytolytic activity in resting NK cells (Miah 2008)
  • functions as an activating receptor, although it also has the potential to function as an inhibitory receptor (Li 2009)
  • as other KIR genes, suppressed by DNA methylation in most T cells, and DNA demethylation promotes their expression through effects on both chromatin structure and transcription factors (Liu 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS