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FLASH GENE
Symbol KIR2DL3 contributors: npt/ - updated : 24-03-2007
HGNC name killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
HGNC id 6331
Location 19q13.42      Physical location : 55.249.973 - 55.264.503
Synonym name
  • natural killer cell immunoglobulin-like inhibitory receptor for HLA-C antigens, 2DL3 associated transcript 2
  • p58.2 MHC class-I specific NK receptor
  • p58 natural killer cell receptor clone CL-6
  • killer cell immunoglobulin-like receptor 2DL3
  • CD158 antigen-like family member B2
  • Synonym symbol(s) NKAT2, p58, CL-6, CD158b, NKAT2A, NKAT2B, CD158B2, GL183, KIR-023GB, KIR-K7c, KIR-K7b, KIRCL23, MGC129943
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text natural killer cell receptor cluster FLNKR@
    STRUCTURE 14.53 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LAIR1 19q13.4 leukocyte-associated Ig-like receptor 1 TTYH1 19q13.4 tweety homolog 1 (Drosophila) LENG8 19q13.42 leukocyte receptor cluster (LRC) member 8 LENG9 19q13.4 leukocyte receptor cluster (LRC) member 9 CDC42EP5 19q13.42 CDC42 effector protein (Rho GTPase binding) 5 LAIR2 19q13.4 leukocyte-associated Ig-like receptor 2 FLJ00060 19q13.42 hypothetical gene FLJ00060 LILRB1 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 LILRA2 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 LILRA1 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 LILRB4 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 ILT9 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member6, pseudogene ILT10 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 5 KIR3DL7 19q13.42 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 5 KIR2DL3 19q13.4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 LOC390973 19 similar to killer-cell Ig-like receptor KIR3DL7 KIR2DL1 19q13.4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 LOC390974 19 similar to 1060P11.3 (killer inhibitory receptor 2-2-2 (KIR222) (KIRX)) LOC388562 19 similar to 1060P11.4.2 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (isoform 2) (KIR103-AS)) KIR3DL1 19q13.4 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 KIR2DS4 19q13.4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 FCAR 19q13.4 Fc fragment of IgA, receptor for NCR1 19q13.42 natural cytotoxicity triggering receptor 1 NALP7 19q13.42 NACHT, leucine rich repeat and PYD containing 7 NALP2 19q13.42 NACHT, leucine rich repeat and PYD containing 7 GP6 19q13.4 glycoprotein VI (platelet) RDH13 19q13.42 retinol dehydrogenase 13 (all-trans and 9-cis)
    RNA
    TRANSCRIPTS type messenger
    text alternatively spliced (truncated) form NKAT2 del Ig2 (Döhring)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1596 37.9 341 - Dohring
    - - 1457 37.9 341 - Dohring
    - - 1134 37.9 341 - Dohring
    - - 1163 - 243 - Dohring
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • an extracellular region containing two C2-type Ig-like domains
  • a 19-amino acid hydrophobic transmembrane region
  • a long cytoplasmic tail with 2 ITIMs (immunoreceptor tyrosine-based inhibitory motifs)
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • functioning as a receptor for class I molecules on NK cells
  • inhibiting the activity of NK cells thus preventing cell lysis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS