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FLASH GENE
Symbol KIR2DL1 contributors: - updated : 08-04-2006
HGNC name killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
HGNC id 6329
Location 19q13.4      Physical location : 55.281.264 - 55.295.778
Synonym name
  • natural killer cell immunoglobulin-like inhibitory receptor for HLA-C antigen, 2DL1 associated transcript 1
  • Synonym symbol(s) NKAT1, 47.11, CL-42, p58.1, CD158A, CD158A, CL-42, KIR-K3, KIR-K64, KIR-K65, KIR-K9, KIR221
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text natural killer cell receptors cluster FLNKR@
    STRUCTURE 16.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - KIR2DL3 - KIR3DP1 - KIR2DL1 - KIR2DL4 - KIR3DL1 -KIR2DS4 - KIR3DL2 - qter
    Authors martin (00)
    Text see FLNKR@
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • a 21-amino acid signal peptide
  • an extracellular region
  • two C2-type Ig-like domains with 5 potential N-linked glycosylation sites
  • a 19-amino acid hydrophobic transmembrane region and an 84-amino acid long cytoplasmic domain
  • two immunoreceptor tyrosine-based inhibitory motifs (ITIM)
  • conjugated GlycoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • inhibiting the activity of NK cells thus preventing cells lysis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS