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FLASH GENE
Symbol KIN contributors: mct/npt - updated : 06/11/2008
HGNC name KIN, antigenic determinant of recA protein homolog (mouse)
HGNC id 6327
Location 10p14      Physical location : 7.797.367 - 7.829.944
Synonym name
  • binding to corved DNA
  • antigenic determinant of recA protein homolog
  • Synonym symbol(s) KIN17, BTCD
    DNA
    TYPE functioning gene
    STRUCTURE 32.57 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1906 45.2 393 - Carlier (2007)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
    Endocrineneuroendocrinepituitary  highly
    Nervousbraindiencephalonhypothalamus  
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a zinc finger motif (residues 28-50) within a 30-kDa N-terminal region conserved from yeast to human
  • a 39 AA domain with significant homology ro recA
  • WH module presenting an additional and highly conserved 3(10)-helix, involved in protein-protein interaction through its conserved surface centered on the 3(10)-helix
  • a 15-kDa C-terminal tandem of SH3-like subdomains, crucial for the anti-proliferation effect
  • secondary structure three-alpha-helix bundle packed against a three-stranded beta-sheet
    HOMOLOGY
    interspecies homolog to murine Kin17
    Homologene
    FAMILY
  • winged helix (WH) family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope,matrix attachement regions
    basic FUNCTION
  • UVC-responsive gene involved inDNA replication (in presence of functional global genome repair)
  • DNA- and RNA-binding protein that plays an important role in nuclear metabolism and in particular in the general response to genotoxics
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    induced by UVC irradiation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    following exposure to ionizing radiations and UV light, depending on the integrity of the global genome repair machinery
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS