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FLASH GENE
Symbol KIFC3 contributors: mct/npt - updated : 07-04-2009
HGNC name kinesin family member C3
HGNC id 6326
Location 16q13      Physical location : 57.792.130 - 57.836.439
Synonym symbol(s) FKIF2, DKFZp686D23201, FLJ34694
DNA
TYPE functioning gene
STRUCTURE 44.31 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D16S408 - D16S3334 - D16S3057 - KIFC3 - D16S3204 - D16S3089 - D16S400 - qter
Authors Hoang (98)
Physical map
SLC12A3 16q13 solute carrier family 12 (sodium/chloride transporters), member 3 HERPUD1 16q12.2-13 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 CETP 16q13 cholesteryl ester transfer protein, plasma NOD27 16q13 nucleotide-binding oligomerization domains 27 CPNE2 16q13 copine II NIP30 16q13 NEFA-interacting nuclear protein NIP30 KIAA1972 16q13 KIAA1972 protein TM4SF11 16q12-q13 transmembrane 4 superfamily member 11 (plasmolipin) BART1 CX3CL1 16q13 chemokine (C-X3-C motif) ligand 1 CCL22 16q13 chemokine (C-C motif) ligand 22 CCL17 16q13 chemokine (C-C motif) ligand 17 LOC57019 16q13-q21 hypothetical protein LOC57019 POLR2C 16q13-q21 polymerase (RNA) II (DNA directed) polypeptide C, 33kDa DOK4 16q13 docking protein 4 MGC10992 16q13 hypothetical protein LOC92922 GPR114 16q13 G protein-coupled receptor 114 LOC255519 16q13 similar to high mobility group protein homolog HMG4 GPR56 16q13 G protein-coupled receptor 56 GPR97 16q13 G protein-coupled receptor 97 DKFZp434I099 16q13 hypothetical protein DKFZp434I099 KATNB1 16q13 katanin p80 (WD repeat containing) subunit B 1 KIFC3 16q13-q21 kinesin family member C3 LOC388282 16 hypothetical gene supported by AF452719; BC041062 CNGB1 16q13 cyclic nucleotide gated channel beta 1 TEPP 16q13 testis/prostate/placenta-expressed protein ZNF319 16q21 zinc finger protein 319 FLJ13154 16q13 hypothetical protein FLJ13154 MMP15 16q13-q21 matrix metalloproteinase 15 (membrane-inserted) GTL3 16q13 likely ortholog of mouse gene trap locus 3 CSNK2A2 16p13.3-p13.2 casein kinase 2, alpha prime polypeptide HSPC065 16q13 HSPC065 protein FLJ13912 16q13 hypothetical protein FLJ13912 NDRG4 16q21-q22.3 NDRG family member 4 FLJ21148 16q13 hypothetical protein FLJ21148 KIAA1007 16q21 hypothetical protein FLJ21148
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3355 77 687 - Xu (2002)
- - 3411 92 826 - Xu (2002)
19 - 3366 92.64 833 - Xu (2002)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Endocrinethyroid    
Reproductivemale systemtestis   
Respiratorylung    
Urinarykidney    
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningretinal pigment epithelium (RPE)  
Epithelialsecretoryglandularendocrine 
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousoptic nerve
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal globular domain
  • the motor domain with an ATP and the microtubule binding sites
  • a long alpa-helical coiled-coil region (stalk region), involved in dimerization
  • a small C-terminal motor domain, potentially involved in interaction with other proteins, vesicles or organelles
  • mono polymer dimer
    HOMOLOGY
    interspecies homolog to murine Kifc3
    Homologene
    FAMILY
  • kinesin-like protein family, microtubule (MT) minus end-directed kinesin superfamily protein
  • CATEGORY motor/contractile , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule
    text in polarized epithelial cells, localized on membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells (Noda 2001)
    basic FUNCTION
  • playing a role in intracellular transport and mitosis
  • plays a complementary role in Golgi positioning and integration with cytoplasmic dynein (Xu 2002)
  • participate in polarized transport in epithelial cells as shown in the apical transport of ANXA13-containing vesicles (Hirokawa 2004)
  • functions as a regulatory or structural element of the adhesion protein complex rather than as a cargo motor (Meng 2008)
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • transported to cell junctions in a manner dependent on the PLEKHA7-NEZHA complex (Meng 2008)
  • cooperates with NEZHA for the maintenance of the zonula adherens (Meng 2008)
  • cell & other
  • micotubules
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS