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FLASH GENE
Symbol KIF5B contributors: mct/npt - updated : 14-10-2014
HGNC name kinesin family member 5B
HGNC id 6324
Location 10p11.22      Physical location : 32.297.939 - 32.345.371
Synonym name
  • kinesin 1
  • kinesin heavy chain, ubiquitous
  • kinesin 1 (110-120kD)
  • ubiquitous kinesin heavy chain
  • conventional kinesin heavy chain
  • epididymis secretory protein Li 61
  • Synonym symbol(s) UKHC, KNS, KNS1, KINH
    DNA
    TYPE functioning gene
    STRUCTURE 47.43 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 5905 - 963 - Morton (2010)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Cardiovascularheart    
    Digestiveliver    
    Nervousbrainlimbic systemhippocampus highly
     nervespinal nervesciatic  
     spinal cord    
    Respiratorylung    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousglia
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal globular domain, the motor domain with an ATP and the microtubule binding sites
  • a long alpa-helical coiled-coil region (stalk region), involved in dimerization
  • a fragment 594910 AAs is sufficient to bind SNAP25 (Morton 2010)
  • a small C terminal domain, potentially involved in interaction with other proteins, vesicles or organelles
  • secondary structure
  • a 64-AA alpha-helix domain in the tail region, which directly interacted with desmin and might be responsible for the transportation of the protein in a complex
  • mono polymer dimer , oligo
    HOMOLOGY
    interspecies homolog to murine Kif5b
    Homologene
    FAMILY
  • kinesin-like protein family
  • kinesin subfamily
  • CATEGORY motor/contractile , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • microtubule associated force-producing, playing a role in organelle transport
  • microtubule-dependent motor required for normal distribution of mitochondria and lysosomes
  • required for bidirectional motility of ER exit sites and efficient ER-to-Golgi transport. (Gupta 2008)
  • essential to anterograde trafficking of a cardiac voltage-gated potassium channel (Zadeh 2009)
  • facilitates the transport of SNAP25 containing vesicles as a prerequisite to SNAP25 driven membrane fusion events (Morton 2010)
  • in addition to its role in organelle transport, an important universal function of KIF2B is to mediate cytoplasmic microtubule-microtubule sliding
  • MAP7 and KIF5B are critical for myonuclear positioning and are not required for fusion and myofibre formation
  • major microtubule motor that drives transport of numerous cellular cargoes toward the plus ends of microtubules
  • is critical in suppressing chromosomal instability at the early stages of female meiotic cell development and mitotic cell division
  • transports MYC for proteasomal degradation in the cytoplasm and the proper degradation of MYC mediated by KIF5B transport is important for transformation activities of MYC
  • KIF5B or KIF9 depletion shows an increase in the fusion index while maintaining a normal number of nuclei per myotube
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex with two kinesins, heavy chain and two light chains (KIF5A, KIF5B, KLC2, KLC1) (Morton 2010)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to synaptosome associated proteins SNAP23 and SNAP25 by their heptad repeats
  • interacting with TRAK1 and TRAK2
  • interacting with RRBP1
  • binding to unpolymerized tubulin
  • critical role of KIF5B-SYBU-mediated axonal transport in the maintenance of presynaptic function and regulation of synaptic plasticity
  • interaction between the cargo-binding domain of kinesin-1 heavy chain KIF5B and the membrane-associated SNARE proteins SNAP25 and SNAP23 (Morton 2010)
  • directly interact with syntabulin (GOLSYN) to mediate anterograde axonal transport of syntaxin-1 containing synaptic vesicles and mitochondria (Morton 2010)
  • requires ensconsin MAP7 for its primary function of organelle transport
  • KIF5B is required for the forward transport and axonal function of SCN10A, suggesting a mechanism for axonal accumulation of SCN10A in inflammatory pain
  • KIF5B directly binds to ankyrin-G (ANK3) to transport Nav channels into axons
  • ZFYVE27 interact with other hereditary spastic paraplegia-related proteins including myelin proteolipid protein 1 (PLP1), atlastin-1 (ATL1), REEP1, REEP5 (similar to REEP1), KIF5A, KIF5B, KIF5C
  • MAP7 cooperates with its binding partner KIF5B during interphase to trigger centrosome separation
  • PLCL1 and GABARAP function in a complex to regulate KIF5B-mediated insulin secretion, providing new insights into insulin exocytic mechanisms
  • cell & other
  • binding to microtubules
  • REGULATION
    activated by RANBP2 (through its kinesin-binding domain KBD, associates in with kinesin-1, KIF5B/KIF5C, and activate the ATPase activity of KIF5B approximately 30-fold in the presence of microtubules and ATP) (Cho 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    KIF5B-RET fusion promotes the cell growth and tumorigenicity of non-small cell lung cancers through multilevel activation of STAT3 signaling
    constitutional     --low  
    in diabetes high glucose decreased KIF5B, SNAP25 and synaptophysin immunoreactivity specifically in axons of hippocampal neurons which may lead to changes in synaptic proteins, thus contributing to changes in hippocampal neurotransmission and to cognitive and memory impairments
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS