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FLASH GENE
Symbol KIF4A contributors: mct - updated : 14-01-2014
HGNC name kinesin family member 4A
HGNC id 13339
Location Xq13.1      Physical location : 69.509.878 - 69.640.773
Synonym name
  • chromokinesin
  • chromosome-associated kinesin KIF4A
  • Synonym symbol(s) KIF4, KIF4G1, KF4A, FLJ12530, FLJ12655, FLJ14204, FLJ20631, HSA271784
    DNA
    TYPE functioning gene
    STRUCTURE 130.90 kb     31 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    HCP43 Xq13.1 cytochrome c, somatic pseudogene TED Xq13.1 TED protein ED1 Xq12-q13.1 ectodermal dysplasia 1, anhidrotic LOC158835 Xq13.1 similar to bA351K23.5 (novel protein) LOC139562 Xq13.1 similar to bA351K23.4 (novel protein) IGBP1 Xq13.1-q13.4 immunoglobulin (CD79A) binding protein 1 FLJ25989 Xq13.1 FLJ25989 protein LOC158833 Xq13.1 hypothetical protein LOC158833 P2RY4 Xq13 pyrimidinergic receptor P2Y, G-protein coupled, 4 ARR3 Xq13.1 arrestin 3, retinal (X-arrestin) LOC347517 Xq13.1 similar to DNA segment, Chr 9, Brigham & Womens Genetics 0185 expressed LOC51248 Xq13.1 hypothetical protein LOC51248 KIF4A Xq13.1 kinesin family member 4A OBDPF Xq13.1 osteoblast differentiation promoting factor DLG3 Xq13.1 discs, large (Drosophila) homolog 3 (neuroendocrine-dlg) TEX11 Xq12-q13.1 testis expressed sequence 11 SLC7A3 Xq12 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 LOC392488 X similar to Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15) SNX12 Xq12-q13.1 sorting nexin 12
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    31 - 4504 - 1232 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Cardiovascularheart    
    Digestiveliver    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver, spleen, thymus, neurons
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • kinesin motor catalytic domain
  • NH2 terminal globular motor domain
  • central alpha-helical stalk domain
  • leucine Zip motif (Zip1) and CR(cysteine-rich) motifs important for chromatin-binding and mitotic function
  • C terminal tail domain, cargo-binding domain
  • HOMOLOGY
    interspecies homolog to murine Kif4
    Homologene
    FAMILY
  • ezrin/radixin/moesin family
  • CATEGORY motor/contractile , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    text
  • predominantly associated with the nuclear matrix during the interphase, while a small portion is found in the cytoplasm
  • localizes to nucleus during interphase of the cell cycle
  • basic FUNCTION
  • required for mitotic chromosomal positioning and bipolar spindle stabilization (microtubule-based mitotic motor)
  • critical for mitotic regulation including chromosome condensation, spindle organization and cytokinesis
  • microtubule-motor molecules that possess chromatin binding activity and is important for mitotic and meiotic regulation
  • role in the DNA damage response by modulating the BRCA2/Rad51 pathway
  • plays a crucial suppressive role in tumorigenesis
  • functions as an inhibitor of gastric cancer cell proliferation
  • even in the absence of spindle bipolarity, PRC1 appears to be essential for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly, whereas KIF4A is required for limiting the length of anaphase microtubules
  • KIF22 and KIF4A contribute independently to the rapid and correct attachment of chromosomes by controlling the positioning of chromosome arms and the dynamics of microtubules, respectively
  • chromokinesins KIF22 and KIF4A promote efficient chromosome congression through the concerted generation of anti-poleward (AP) force and the regulation of spindle MT dynamics
  • mainly contributes to MT dynamics and both together with KIF22 are required for chromosome congression to the metaphase plate
  • PRC1 and KIF4A, two microtubule-associated proteins required for midzone assembly, can tag microtubule plus ends
  • anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A
  • KIF4A and PPP2R5C and PPP2R5E therefore create a spatially restricted negative feedback loop counteracting AURKB in anaphase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with HGM20B through their respective alpha-helical coiled-coil domains
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with BRCA2 in a biochemical identification and the interaction is mediated by the KIF4A C-terminal cargo-binding domain and BRCA2 C-terminal conserved region
  • interacting with PRC1 (cell cycle-dependent translocation of PRC1 by KIF4A is essential for midzone formation and cytokinesis)
  • targeted to chromosomes via the noncatalytic activity of PPP2R4
  • PPP2R5C can dephosphorylate the T799 AURKB site on KIF4A and thereby counteract the AURKB- and microtubule-stimulated ATPase activity of KIF4A
  • cell & other
    REGULATION
    Phosphorylated by AURKB (KIF4A phosphorylation by Aurora B stimulates the maximal microtubule-dependent ATPase activity of KIF4A and promotes its interaction with PRC1)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS