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FLASH GENE
Symbol KIF3C contributors: mct - updated : 28-09-2017
HGNC name kinesin family member 3C
HGNC id 6321
Location 2p23.3      Physical location : 26.149.454 - 26.205.443
Synonym symbol(s) KF3C
DNA
TYPE functioning gene
STRUCTURE 55.98 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC391356 2 similar to ENSANGP00000018456 MGC11266 2p24.1 hypothetical protein MGC11266 ADCY3 2p23 adenylate cyclase 3 LOC51277 LOC388934 2 LOC388934 LOC388935 2 LOC388935 KIAA0953 2p24.1 LOC388935 POMC 2p23.3 proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin) DNMT3A 2p23 DNA (cytosine-5-)-methyltransferase 3 alpha DTNB 2p23-p22 dystrobrevin, beta ASXL2 2p24.1 additional sex combs like 2 (Drosophila) KIF3C 2p23 kinesin family member 3C LOC391357 2 similar to Ubiquinol-cytochrome C reductase complex 11 kDa protein, mitochondrial precursor (Mitochondrial hinge protein) (Cytochrome C1, nonheme 11 kDa protein) (Complex III subunit VIII) LOC391358 2 similar to hypothetical protein HSPC152 RAB10 2p24.1 RAB10, member RAS oncogene family LOC391359 2 similar to Epithelial membrane protein-2 (EMP-2) (XMP protein) LOC130482 2p24.1 similar to SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1; mammalian chromatin remodeling complex BRG1-associated factor 57 PPIL1P1 2p23.3 peptidylprolyl isomerase (cyclophilin)-like 1 pseudogene 1 LOC150946 2p24.1 hypothetical protein LOC150946 HADHA 2p23 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit HADHB 2p23 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit GPR113 2p24.1 G protein-coupled receptor 113 KIAA1724 2p24.1 selenoprotein I, 1 MGC16372 2p24.1 CG10958-like OTOF 2p23-p22 otoferlin LOC388936 2 similar to RIKEN cDNA 1700001C02 LOC130106 2p24.1 similar to Calcium and integrin-binding protein 1 (Calmyrin) (DNA-PKcs interacting protein) (Kinase interacting protein) (KIP) (CIB) KCNK3 2p24.1-p23.1 potassium channel, subfamily K, member 3 FLJ20555 CENPA 2p23.1-p22.3 centromere protein A, 17kDa DPYSL5 2p23-p21 dihydropyrimidinase-like 5 MAPRE3 2p23.3-p23.1 microtubule-associated protein, RP/EB family, member 3 FLJ20254 2p23.3 hypothetical protein FLJ20254 FLJ21839 2p23.3 hypothetical protein FLJ21839 EMILIN1 2p23.3-p23.2 elastin microfibril interfacer 1 KHK 2p23.3-p23.2 ketohexokinase (fructokinase) CGREF1 2p23.3 cell growth regulator with EF hand domain 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 5431 - 793 - 2007 17881655
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Nervousbrain   highly Homo sapiens
Reproductivemale systemprostate   
Respiratorylung    
Visualeyeretina  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal globular domain, the motor domain with an ATP and the microtubule binding sites
  • a long alpa-helical coiled-coil region (stalk region), involved in dimerization
  • a small C terminal domain, potentially involved in interaction with other proteins, vesicles or organelles
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Kif3c
    homolog to Drosophila Klp68D
    homolog to C.elegans klp-11
    Homologene
    FAMILY
  • kinesin-like protein family of microtubule-associated motor proteins
  • kinesin II subfamily
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • acting as microtubule-based anterograde translocator for membranous organelles
  • playing a role in various intracellular transport and spindle formation
  • KIF3B mutant photoreceptor cilia differentiate with a delay, suggesting that KIF3C, although redundant with KIF3B at later stages of differentiation, is not active early in photoreceptor ciliogenesis
  • is a key regulator of axonal growth and regeneration by controlling microtubule dynamics and organization in the growth cone
  • KIF3C is an injury-specific kinesin that contributes to axon growth and regeneration by regulating and organizing the microtubule cytoskeleton in the growth cone
  • functions as a motor protein involved in axonal transport in neuronal cells
  • KIF3A, KIF3B, KIF3C is classified as a heterotrimeric kinesin-2 that is best known for organelle transport in neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text non-selective vesicle transport
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of KIF3A and KIF3C
  • intermolecular communication within the KIF3AC heterodimer modulates entry into the processive run regardless of whether the run is initiated by the KIF3A or KIF3C motor domain
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • FMR1-interacting protein (FMR1 is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of KIF3C in breast cancer may be associated with the tumor progression and metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS