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FLASH GENE
Symbol KIF3B contributors: mct/npt/pgu - updated : 28-09-2017
HGNC name kinesin family member 3B
HGNC id 6320
Location 20q11.21      Physical location : 30.865.453 - 30.922.809
Synonym name
  • microtubule plus end-directed kinesin motor 3B
  • kinesin-like protein KIF3B
  • Synonym symbol(s) KIAA0359, HH0048, FLA8, KLP-11
    EC.number 3.6.4.4
    DNA
    TYPE like-sequence
    STRUCTURE 57.35 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    DEFB123 20q11.1 defensin, beta 123 REM 20q11.1 RAS (RAD and GEM)-like GTP-binding LOC388794 20 similar to dJ1093G12.6 (A novel protein) HM13 20q11.21 histocompatibility (minor) 13 ID1 20q11 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein COX4I2 20q11.21 cytochrome c oxidase subunit IV isoform 2 BCL2L1 20q11.1 BCL2-like 1 TPX2 20q11.2 TPX2, microtubule-associated protein homolog (Xenopus laevis) MYLK2 20q13.31 myosin light chain kinase 2, skeletal muscle FKHL18 20q11.1-q11.2 forkhead-like 18 (Drosophila) DUSP15 20 dual specificity phosphatase-like 15 LOC164395 20q11.21 hypothetical protein LOC164395 C20orf126 20q11.21 chromosome 20 open reading frame 126 LOC343702 20q11.21 similar to dJ310O13.4 (novel protein similar to predicted C. elegans and C. intestinalis proteins) C20orf160 20q11.2 chromosome 20 open reading frame 160 HCK 20q11.21 hemopoietic cell kinase TM9SF4 20q11.21 transmembrane 9 superfamily protein member 4 RPL24P1 20q11 ribosomal protein L24 pseudogene 1 TSPYL3 20q11.1 TSPY-like 3 PLAGL2 20q11.1 pleiomorphic adenoma gene-like 2 POFUT1 20q11 protein O-fucosyltransferase 1 KIF3B 20p11.2-q11.21 kinesin family member 3B ASXL1 20q11 additional sex combs like 1 (Drosophila) DKFZP566G1424 20q11.1-q11.23 hypothetical protein DKFZp566G1424 C20orf112 20q11.1-q11.23 chromosome 20 open reading frame 112 LOC284804 20q11.21 hypothetical protein LOC284804 LOC149950 20q11.21 hypothetical LOC149950 FLJ33706 20q11.22 hypothetical protein FLJ33706 C20orf92 20q11.22 chromosome 20 open reading frame 92 DNMT3B 20q11.2 DNA (cytosine-5-)-methyltransferase 3 beta MAPRE1 20q11.1-q11.23 microtubule-associated protein, RP/EB family, member 1 LOC388795 20 similar to hypothetical protein FLJ33620 SPAG4L 20q11.21 sperm associated antigen 4-like BPIL1 20q11.21 bactericidal/permeability-increasing protein-like 1 BPIL3 20q11.22 bactericidal/permeability-increasing protein-like 3 LOC391242 20 similar to DNA segment, numerous copies, expressed probes (GS1 gene) C20orf185 20q11.21 chromosome 20 open reading frame 185 C20orf186 20q11.21 chromosome 20 open reading frame 186
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 6135 85.1 747 - 1999 10548469
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Urinarykidney   highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • globular N terminal domain
  • a central motor domain with an ATP binding site
  • a coiled-coil domain
  • a C terminal alpha helical tail, responsible for heterodimerization
  • HOMOLOGY
    interspecies homolog to murine kinesin KIF3B
    homolog to C.elegans y50d7a.6
    Homologene
    FAMILY
  • kinesin family 3
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text cilia
    basic FUNCTION
  • basic ciliary activity-putatively involved in the nodal flow supposed to break symetry
  • kinesin-2 complex (KIF3A, KIF3B) plays an important role not only in interphase but also in mitosis
  • PKP4 and ECT2 are transported via distinct motors, identifying a novel pathway implicating KIF3B in the regulation of actin organization during cytokinesis
  • heterotrimeric motor protein that facilitates fast anterograde translocation of membranous organelles
  • involved in the trafficking of SLC4A1 to the plasma membrane of kidney alpha-intercalated cells
  • playing a role in SLC4A1 trafficking to the plasma membrane
  • KIF3B mutant photoreceptor cilia differentiate with a delay, suggesting that KIF3C, although redundant with KIF3B at later stages of differentiation, is not active early in photoreceptor ciliogenesis
  • KIF3A, KIF3B (KIF3AB) is an N-terminal processive kinesin-2 family member best known for its role in intraflagellar transport
  • the kinesin-2 family motor KIF3A/KIF3B works together with dynein to bidirectionally transport intraflagellar particles, melanosomes, and neuronal vesicles
  • KIF3A, KIF3B, KIF3C is classified as a heterotrimeric kinesin-2 that is best known for organelle transport in neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text determination of left-right asymmetry, intracellular organelle transport
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • heterodimere of KIF3A and KIF3P
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CSPG6
  • associating with PKHD1 and PKD2 (mediates the regulation of PKD2 channel function by PKHD1)
  • interaction with ARHGEF10 (KIF3B may modulate the ARHGEF10-RhoA pathway through the binding to ARHGEF10)
  • CLCN5 interacts with kinesin family member 3B (C-terminus of CLCN5 and the coiled-coil and globular domains of KIF3B were shown to interact) (KIF3B)
  • SLC4A1 interacts with KIF3B in the kidney tissue (a dileucine motif at the C-terminal SLC4A1 contributes to its interaction with KIF3B)
  • RNF33 most likely interacted with KIF3A-KIF3B independent of the adaptor kinesin-associated protein KIFAP3
  • GLI1 interactions with KIF3A-KIF3B-KIFAP3 complexes are essential for proper GLI1 transcriptional activity
  • PKP4 directly interacts with the KIF3/subunit KIF3B, and also interacts with the kinesin cargo adaptor protein KIFAP3 acting as a stabilizing linker between KIF3B and its KIFAP3 cargo binding entity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma (HCC)tumor tissues and proliferating HCC cells, and an increased KIF3B expression was associated with poor overall survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    murine Kif3b-/- have randomized situs