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FLASH GENE
Symbol KIF2B contributors: mct - updated : 28-06-2017
HGNC name kinesin family member 2B
HGNC id 29443
Location 17q22      Physical location : 51.900.238 - 51.902.573
Synonym name
  • kinesin-like protein KIF2B
  • testis tissue sperm-binding protein Li 82P
  • DNA
    TYPE functioning gene
    STRUCTURE 2.34 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2335 76 673 - 2001 11416179
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer complex
    HOMOLOGY
    interspecies ortholog to C. elegans klp-7
    ortholog to drosophila Klp59C and Klp59D
    ortholog to murine Kif2b
    Homologene
    FAMILY
  • kinesin-like protein family
  • MCAK/KIF2 subfamily
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    intracellular,nucleus,nucleolus
    text localizes to outer kinetochores during prometaphase and has been shown to be required for the correction of of kinetochore-microtubule (k-MT) attachment errors during that stage of mitosis
    basic FUNCTION
  • involved in microtubule-based movement
  • its function is required for spindle assembly and chromosome movement and the microtubule depolymerase activities of KIF2A, KIF2B, and KIF2C fulfill distinct functions during mitosis in human cells.
  • microtubule-depolymerizing kinesin, that stimulate kinetochore-microtubule dynamics during distinct phases of mitosis to correct mal-orientations
  • in early mitosis, a KIF2B–KIF2C complex is recruited to kinetochores to promote chromosome movement, kinetochore–microtubule turnover, correction of attachment errors, and maintenance of SAC signalling
  • KIF2C, SPAG5 and KIF2B form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • microtubule associated complex
  • GSK3B-SKAP-KIF2B signaling axis constitutes a dynamic link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • physically associates with KIF2C and SPAG5
  • PLK1 regulates both the localization and activity of KIF2B during mitosis to promote the correction of k-MT attachment errors to ensure mitotic fidelity
  • CEP170 and CEP170B (KIAA0284) are specifically associating with KIF2B
  • cell & other
    REGULATION
    Phosphorylated by PLK1 (PLK1 directly phosphorylates KIF2B at threonine 125 (T125) and serine 204 (S204), and these two sites differentially regulate KIF2B function)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS