SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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| intracellular,nucleus,nucleolus
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| localizes to outer kinetochores during prometaphase and has been shown to be required for the correction of of kinetochore-microtubule (k-MT) attachment errors during that stage of mitosis |
basic FUNCTION
| involved in microtubule-based movement |
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its function is required for spindle assembly and chromosome movement and the microtubule depolymerase activities of KIF2A, KIF2B, and KIF2C fulfill distinct functions during mitosis in human cells. |
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microtubule-depolymerizing kinesin, that stimulate kinetochore-microtubule dynamics during distinct phases of mitosis to correct mal-orientations |
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in early mitosis, a KIF2B–KIF2C complex is recruited to kinetochores to promote chromosome movement, kinetochore–microtubule turnover, correction of attachment errors, and maintenance of SAC signalling |
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KIF2C, SPAG5 and KIF2B form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity |