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FLASH GENE
Symbol KIF2A contributors: shn/npt - updated : 28-08-2016
HGNC name kinesin heavy chain member 2A
HGNC id 6318
Corresponding disease
CDCBM3 cortical dysplasia, complex, with other brain malformations 3
Location 5q12.1      Physical location : 61.601.988 - 61.682.209
Synonym name
  • kinesin, heavy chain, 2
  • kinesin-like protein KIF2A
  • Synonym symbol(s) HK2, KIF2, KNS2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text in tandem with IPO11, LRRC70
    STRUCTURE 81.02 kb     19 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D5S1990 - D5S1474 - KIF2A - D17S829 - D5S427 - tel
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 4058 - 706 - 2007 17538014
    21 - 4172 - 744 - 2007 17538014
    21 - 4261 - 686 - 2007 17538014
    21 - 4001 - 687 - 2007 17538014
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     thymus   highly
    Nervousbrain   highly Homo sapiensFetal
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal globular domain, the motor domain with an ATP and the microtubule binding sites
  • a long alpa-helical coiled-coil region (stalk region), involved in dimerization
  • a small C terminal domain, potentially involved in interaction with other proteins, vesicles or organelles
  • HOMOLOGY
    interspecies ortholog to Kif2a, Mus musculus
    ortholog to Kif2a, Rattus norvegicus
    Homologene
    FAMILY
  • kinesin-like protein family
  • MCAK/KIF2 subfamily
  • CATEGORY motor/contractile , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • cytosolic protein
  • basic FUNCTION
  • anterogradely transporting vesicles important for axonal extension in developing neurons
  • regulates microtubule dynamics during axonal growth
  • induces microtubule depolymerization
  • implicated in formation of bipolar mitotic spindles
  • involved in regulating axonal collateral branching
  • depolymerizes microtubules (MTs) at growth cones and regulates axon pathfinding
  • controls the length and alignment of central spindle MTs through depolymerization at their minus ends
  • Aurora B and KIF2A control microtubule length for assembly of a functional central spindle during anaphase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • endogenous VHL binding partner (have overlapping functions regarding primary cilia regulation)
  • PIP5K1A suppressed the elongation of axon branches in a KIF2A-dependent manner, suggesting a unique PIPK-mediated mechanism controlling MT dynamics in neuronal development
  • activation of KIF2A is not sufficient but is essential for the function of PIP5K1A
  • TTBK2 with MAPRE1/MAPRE3 phosphorylates KIF2A and antagonizes KIF2A-induced depolymerization at microtubules plus ends for cell migration
  • cell & other
    REGULATION
    Other regulated positively by PLK1 and negatively by Aurora A
    ASSOCIATED DISORDERS
    corresponding disease(s) CDCBM3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Brains of kif2a(-/-) mice showed aberrant axonal branching due to overextension of collateral branches and microtubule-depolymerizing activity decreased in growth cones