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FLASH GENE

Symbol

KIF26A

contributors: npt/SGE - updated : 04-02-2010

HGNC name	kinesin family member 26A
HGNC id	20226

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q32.33      Physical location : 104.605.059 - 104.647.234
Synonym name	KIF26A variant protein
Synonym symbol(s)	KIAA1236, DKFZP434N178, FLJ22753

DNA

TYPE	functioning gene
STRUCTURE	42.18 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015656 15 - 6757 NP_056471 194.5 1882 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Lymphoid/Immune spleen         Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one kinesin-motor domain

conjugated

PhosphoP

HOMOLOGY

intraspecies

homolog to KIF3A

Homologene

FAMILY	kinesin-like protein family
	KIF26 subfamily

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION

playing a key role in enteric neuron development, acting by repressing a cell growth signaling pathway in the enteric nervous system development (Zhou 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , nervous system

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP binding

protein

interacting with GRB2

cell & other

binding to microtubules but lacking microtubule-based motility due to the absence of ATPase activity

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Kif26a -/- mice showed growth retardation, became emaciated, and died within 5 weeks of birth. Kif26a -/- mice exhibited megacolon and enteric nerve hyperplasia due to Gdnf hyperresponsiveness, resulting in disturbed bowel movement regulation and dilation of the gastrointestinal tract. (Zhou 2009)