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FLASH GENE
Symbol KIF23 contributors: mlc/npt - updated : 10-01-2017
HGNC name kinesin family member 23
HGNC id 6392
Corresponding disease
CDAN3 congenital dyserythropoietic anemia, type III
Location 15q23      Physical location : 69.706.687 - 69.740.759
Synonym name
  • kinesin-like 5 (mitotic kinesin-like protein 1)
  • mitotic kinesin-like 1
  • Synonym symbol(s) CHO1, KNSL5, MKLP1, MKLP-1
    DNA
    TYPE functioning gene
    STRUCTURE 34.18 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC145853 15q22.31 similar to ENSANGP00000021391 MAP2K5 15q22.2-q22.31 mitogen-activated protein kinase kinase 5 LOC390598 15 similar to RIKEN cDNA C230094B15 LOC388129 15 hypothetical gene supported by BC033162 LOC390599 15 similar to 40S ribosomal protein S15a PIAS1 15q21.3-q22.1 protein inhibitor of activated STAT, 1 MGC4809 15q22.2 serologically defined breast cancer antigen NY-BR-20 CLN6 15q23 ceroid-lipofuscinosis, neuronal 6, late infantile, variant FEM1B 15q22 fem-1 homolog b (C. elegans) ITGA11 15q22.3-q23 integrin, alpha 11 CORO2B 15q22-q23 coronin, actin binding protein, 2B ANP32A 15q22-q23 acidic (leucine-rich) nuclear phosphoprotein 32 family, member A FLJ11722 15q22.31 hypothetical protein FLJ11722 LOC390600 15 similar to RIKEN cDNA 2810413N20 NOX5 15q22.31 NADPH oxidase, EF hand calcium-binding domain 5 SPESP1 15q22.31 sperm equatorial segment protein 1 FLJ33768 15q22.31 hypothetical protein FLJ33768 GLCE 15q22.31 glucuronyl C5-epimerase MPRG 15q22.31 glucuronyl C5-epimerase KIF23 15q22-q23 kinesin family member 23 RPLP1 15q22 ribosomal protein, large, P1 LOC388130 15 LOC388130 LOC388131 15 LOC388131 TLE3 15q22 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) UACA 15q22-q24 uveal autoantigen with coiled-coil domains and ankyrin repeats LOC123397 15q22.32 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) FLJ11196 15q22.32 acheron LOC390601 15 similar to keratin 8, type II cytoskeletal - human THAP10 15q22.32 THAP domain containing 10 FLJ20156 15q22.32 hypothetical protein FLJ20156 LOC283675 15q22.32 similar to ribosomal protein L5; 60S ribosomal protein L5 LOC196993 15q22.32 hypothetical protein LOC196993 LOC390602 15 similar to High mobility group protein 1 (HMG-1) (Amphoterin) (Heparin-binding protein p30) LOC196994 15q22.32 similar to hypothetical protein LOC388132 15 similar to 60S ribosomal protein L17 (L23)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 3415 - 856 - 2013 23562843
    23 - 3727 110 960 coexpressed with variant 1 2013 23562843
  • CHO1 variant - Isof 1
  • interacting with F actin, involved in the terminal phase of cytokinesis
  • 21 - 3338 - 765 - 2013 23562843
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Lymphoid/Immunethymus   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone  highly
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a motor domain involved in the dendritic distribution
  • a tail domain involved in axonal appearance
  • a stalk domain
  • HOMOLOGY
    Homologene
    FAMILY
  • kinesin-like protein family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    text
  • localizing (in vitro) to the interzone of mitotic spindle
  • localized to the dendrite of the developed neuron
  • is a nuclear protein that localizes to the interzone of mitotic spindles, acting as a plus-end-directed motor enzyme that moves antiparallel microtubules in vitro
  • basic FUNCTION
  • cross-binding antiparallel microtubules and driving microtubule movement in vitro
  • component of intercellular bridges during spermatogenesis, is also a component of male and female embryonic intercellular bridges (Greenbaum 2009)
  • conserved mitotic kinesin crucial for cytokinesis
  • strongly supporting function of KIF23 in cytokinesis, and its TP53-dependent repression may contribute to the prevention of uncontrolled cell growth
  • both KIF23 and RACGAP1 are required for efficient microtubule bundling
  • transport organelles within cells and move chromosomes during cell division
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • expression of ECT2, RACGAP1, and KIF23 is tightly regulated during cell cycle progression
  • CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes ECT2, RACGAP1, and KIF23 in S phase
  • RACGAP1 is a crucial regulator of RAC1 in adherent cells and that inhibition of RAC1-dependent effector pathways in anaphase is needed for cytokinesis
  • SRC inhibits likely cytokinesis through the delocalization of KIF23 and AURKB from the spindle midzone, resulting in binucleation
  • is a new transcriptional target gene of the tumor suppressor protein TP53
  • TRAF6 mediates ubiquitination of the midbody ring localized protein KIF23/MKLP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDAN3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the great majority of metastatic lymph nodes from advanced lung cancers and primary lung tumors
    tumoral     --low  
    decreases proliferation of glioma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a new novel prognostic biomarker with potential therapeutic implications in glioma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    be a novel therapeutic target for lung cancer patients
    cancerbrainglioma/neuroblstoma
    may be a novel therapeutic target in malignant glioma
    ANIMAL & CELL MODELS