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FLASH GENE

Symbol

KIF23

contributors: mlc/npt - updated : 10-01-2017

HGNC name	kinesin family member 23
HGNC id	6392

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CDAN3 congenital dyserythropoietic anemia, type III
Location	15q23      Physical location : 69.706.687 - 69.740.759
Synonym name	kinesin-like 5 (mitotic kinesin-like protein 1)
	mitotic kinesin-like 1
Synonym symbol(s)	CHO1, KNSL5, MKLP1, MKLP-1

DNA

TYPE	functioning gene
STRUCTURE	34.18 kb     23 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004856 22 - 3415 NP_004847 - 856 - 2013 23562843 NM_138555 23 - 3727 NP_612565 110 960 coexpressed with variant 1 2013 23562843 CHO1 variant - Isof 1 interacting with F actin, involved in the terminal phase of cytokinesis NM_001281301 21 - 3338 NP_001268230 - 765 - 2013 23562843

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Lymphoid/Immune thymus       highly Reproductive male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone     highly Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a motor domain involved in the dendritic distribution
	a tail domain involved in axonal appearance
	a stalk domain

HOMOLOGY

Homologene

FAMILY

kinesin-like protein family

CATEGORY

transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
	intracellular,nucleus,nucleoplasm
text	localizing (in vitro) to the interzone of mitotic spindle
	localized to the dendrite of the developed neuron
	is a nuclear protein that localizes to the interzone of mitotic spindles, acting as a plus-end-directed motor enzyme that moves antiparallel microtubules in vitro

basic FUNCTION	cross-binding antiparallel microtubules and driving microtubule movement in vitro
	component of intercellular bridges during spermatogenesis, is also a component of male and female embryonic intercellular bridges (Greenbaum 2009)
	conserved mitotic kinesin crucial for cytokinesis
	strongly supporting function of KIF23 in cytokinesis, and its TP53-dependent repression may contribute to the prevention of uncontrolled cell growth
	both KIF23 and RACGAP1 are required for efficient microtubule bundling
	transport organelles within cells and move chromosomes during cell division

CELLULAR PROCESS	cell cycle, division, mitosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	expression of ECT2, RACGAP1, and KIF23 is tightly regulated during cell cycle progression
	CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes ECT2, RACGAP1, and KIF23 in S phase
	RACGAP1 is a crucial regulator of RAC1 in adherent cells and that inhibition of RAC1-dependent effector pathways in anaphase is needed for cytokinesis
	SRC inhibits likely cytokinesis through the delocalization of KIF23 and AURKB from the spindle midzone, resulting in binucleation
	is a new transcriptional target gene of the tumor suppressor protein TP53
	TRAF6 mediates ubiquitination of the midbody ring localized protein KIF23/MKLP1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CDAN3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in the great majority of metastatic lymph nodes from advanced lung cancers and primary lung tumors tumoral     --low   decreases proliferation of glioma cells

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	is a new novel prognostic biomarker with potential therapeutic implications in glioma
Therapy target
	System Type Disorder Pubmed cancer lung   be a novel therapeutic target for lung cancer patients cancer brain glioma/neuroblstoma may be a novel therapeutic target in malignant glioma

ANIMAL & CELL MODELS