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FLASH GENE
Symbol KIF21B contributors: mct/npt - updated : 28-12-2018
HGNC name kinesin family member 21B
HGNC id 29442
Location 1q32.1      Physical location : 200.938.519 - 200.992.828
Synonym symbol(s) KIAA0449, DKFZP434J212, FLJ16314
DNA
TYPE functioning gene
STRUCTURE 54.31 kb     34 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
34 - 9895 - 1624 - Barrett (2008)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
 brainlimbic systemhippocampus   Homo sapiens
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N terminal motor domain interacting with the microtubule track
  • a central coiled-coil stalk
  • a domain of seven WD-40 repeats, which may be involved in binding to cargoes (Marszalek 1999)
  • a C terminal tail interacting with the transported cargo
  • HOMOLOGY
    Homologene
    FAMILY
  • plus end-directed kinesin motor proteins family
  • kinesin-like protein family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • highly enriched in dendrites (Marszalek 1999)
  • KIF11, 21B, 13B with distinct effects on synaptic transmission are expressed in the same hippocampal neuron
  • basic FUNCTION
  • involved in the microtubule-dependent transport of cargo in neurons
  • having plus end-directed motor activity and its enrichment in dendrites indicate that models suggesting that minus end-directed motor activity is sufficient for dendrite specific motor localization are inadequate (Marszalek 1999)
  • plus end-directed kinesin-like protein (KLP) involved in neuronal (axonal) transport
  • its depletion decreases both the fusion index and the number of nuclei per myotube, suggesting a dual role, one for nuclear alignment and one for differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • brain-specific type of KIF21 protein, also interacted with KANK1 (Kakinuma 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to multiple sclerosis
    Variant & Polymorphism SNP rs12122721 associated with multiple sclerosis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS