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FLASH GENE

Symbol

KIF21B

contributors: mct/npt - updated : 28-12-2018

HGNC name	kinesin family member 21B
HGNC id	29442

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q32.1      Physical location : 200.938.519 - 200.992.828
Synonym symbol(s)	KIAA0449, DKFZP434J212, FLJ16314

DNA

TYPE	functioning gene
STRUCTURE	54.31 kb     34 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017596 34 - 9895 NP_060066 - 1624 - Barrett (2008)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain           brain limbic system hippocampus     Homo sapiens Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N terminal motor domain interacting with the microtubule track
	a central coiled-coil stalk
	a domain of seven WD-40 repeats, which may be involved in binding to cargoes (Marszalek 1999)
	a C terminal tail interacting with the transported cargo

HOMOLOGY

Homologene

FAMILY	plus end-directed kinesin motor proteins family
	kinesin-like protein family

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule
text	highly enriched in dendrites (Marszalek 1999)
	KIF11, 21B, 13B with distinct effects on synaptic transmission are expressed in the same hippocampal neuron

basic FUNCTION	involved in the microtubule-dependent transport of cargo in neurons
	having plus end-directed motor activity and its enrichment in dendrites indicate that models suggesting that minus end-directed motor activity is sufficient for dendrite specific motor localization are inadequate (Marszalek 1999)
	plus end-directed kinesin-like protein (KLP) involved in neuronal (axonal) transport
	its depletion decreases both the fusion index and the number of nuclei per myotube, suggesting a dual role, one for nuclear alignment and one for differentiation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

brain-specific type of KIF21 protein, also interacted with KANK1 (Kakinuma 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to multiple sclerosis

Variant & Polymorphism SNP	rs12122721 associated with multiple sclerosis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS