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FLASH GENE
Symbol KIF18B contributors: mct/npt/pgu - updated : 23-03-2011
HGNC name kinesin family member 18B
HGNC id 27102
Location 17q21.31      Physical location : 43.003.448 - 43.025.082
DNA
TYPE anonymous DNA segment
STRUCTURE 21.63 kb     16 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2669 92 842 - 2005 16084724
  • RNA expression level of isoform 1 is generally greater than that of isoform 2
  • - splicing 2569 - 873 - 2010 20600703
  • RNA expression level of isoform 1 is generally greater than that of isoform 2
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonamygdala highly Homo sapiens
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, G2
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • kinesin-like protein family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • predominantly in the nucleus and to a lesser extent in the cytoplasm of interphase cell
  • associated with the spindle of prometaphase (or possibly prophase, although not examined in this study) through metaphase during mitosis
  • microtubule (MT) plus-tip-tracking protein that localizes to the nucleus in interphase and is enriched at astral MT plus ends during early mitosis
  • basic FUNCTION
  • key players or 'hub' proteins in the intracellular transport system, which is essential for cellular function and morphology
  • cell cycle-regulated kinesin that may mainly function during mitosis
  • degraded during anaphase of the cell cycle and may play an important role(s) in regulating cell division
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KIF18B is a new MT dynamics regulatory protein that interacts with MAPRE1 to control astral MT length
  • cell & other
    REGULATION
    Other expression of KIF18B is regulated in a cell cycle-dependent manner and therefore may play an important role(s) in cell division
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS