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FLASH GENE
Symbol KIF17 contributors: np/mct - updated : 24-08-2017
HGNC name kinesin family member 17
HGNC id 19167
Location 1p36.12      Physical location : 20.990.508 - 21.044.317
Synonym name
  • KIF3-related motor protein
  • kinesin-like protein KIF17
  • KIF17 variant protein
  • osmotic avoidance abnormal-3
    • Synonym symbol(s) KIAA1405, KIF17B, KIF3X, KLP-2, OSM-3
    DNA
    TYPE functioning gene
    STRUCTURE 55.72 kb     15 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3807 - 1028 restricted to testis (inner rim of seminiferous tubuli) 2000 10846156
  • KIF17b
  • control CREM-dependent transcription in male germ cells by regulating the intracellular location of the transcriptional coactivator activator of CREM in testis
  • able to shuttle between the nuclear and the cytoplasmic compartments and to transport ACT are neither dependent on its motor domain nor on microtubule
  • physically interacts with a testis-specific member of the PIWI/Argonaute family, PIWIL1 a component of chromatoid bodies implicated in RNA metabolism
    • 15 - 3810 - 1029 - 2000 10846156
    15 - 4130 - 929 - 2000 10846156
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonhypothalamus highly
     braindiencephalonamygdala highly
    Reproductivefemale systemplacenta    Homo sapiens
     male systemtestis  specific
    Visualeyeretina  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentralgray matter  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousglia
    Nervousneuron
    Visualcone photoreceptor
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two putative STALK domains forming an alpha helical coiled-coil
  • a ciliary localization signal (CLS) in the tail domain that is necessary and sufficient for ciliary targeting
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to C. elegans Osm-3
    Homologene
    FAMILY
  • kinesin-like protein family
    • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    text
  • expressed in distal dendrites
  • nuclear and cytoplasmic in round spermatids
  • colocalizes with SPATIAL in dendrites of hippocampal neurons
  • accumulated at the distal tip of the primary cilium
    • basic FUNCTION
  • mediating fast intracellular transport
  • playing a role in the active transport and regulation of GRIN2B in living hippocampal neurons, and transporting GRIN2B-containing vesicles along microtubule in neuronal dendrites
  • required for olfactory cyclic nucleotide-gated (CNG) channel targeting, providing novel insights into mechanisms of mammalian ciliary transport
  • probably the motor that transports KCND2 to dendrites but suggest that this motor does not, by itself, specify dendritic localization of the channel
  • role in dendritic trafficking in neurons
  • essential for photoreceptor outer segment development, suggesting that KIF17 plays a cell type specific role in vertebrate ciliogenesis
  • having different roles in photoreceptor development and maintenance
  • implicated in microtubule stabilization events that contribute to epithelial polarization and morphogenesis
  • KIF17 is implicated in epithelial polarity and morphogenesis, placental transport and development, and the development of specific brain regions
  • novel and direct role for KIF17 in regulating MT dynamics
  • kinesin-2 motor KIF17 regulates microtubule (MT) dynamics and organization to promote epithelial differentiation
  • KIF17 and KIF3A do not act synergistically and did not prevent rhodopsin trafficking to rod outer segments
  • can modify RhoA-GTPase signaling to influence junctional actin and the stability of the apical junctional complex of epithelial cells
  • could likely act as a modifying locus affecting disease penetrance or expressivity in NPHP patients
  • ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46-TTC26 as well as on its nuclear localization signal
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • APBA1, GRIN2B
  • interacts with GRIK2 and GRIK5 subunits and is required for GRIK1 localization to distal dendrites, defining a novel mechanism that controls receptor localization in neurons
  • interacting with SPATIAL (may play a role in neuronal morphogenesis and synaptic plasticity through its interaction with the kinesin motor KIF17 in dendrites)
  • NRF1 co-regulates oxidative enzymes that generate energy and neurochemicals that consume energy related to glutamatergic neurotransmission, such as KIF17, GRIN1, and GRIN2B, thereby ensuring that energy production matches energy utilization at the molecular and cellular levels
  • KIF17 differentially maintains the levels of GRIN2A and GRIN2B, and, when synapses are stimulated, the GRIN2B/KIF17 complex is upregulated on demand through CREB activity
  • KIF17 interaction with NXF2 enables the transport of mRNA bidirectionally in dendrites
  • MAPRE1 recruits KIF17 to dynamic microtubules (MTS), enabling its accumulation at MT ends and thus promoting MT stabilization at discrete cellular domains
  • KIF17 needs to bind to regulatory proteins like RAB23 for its ciliary transport, and RAB23 could mediate the transport of KIF17 to the primary cilium
  • interaction between KIF17, a kinesin 2 family motor, and septin 9 (SEPT9), and SEPT9 modulates likely the interactions of KIF17 with membrane cargo
  • NUP62 and the C termini of NPHP4 and IQCB1 interact with KIF17 and thus spatially map to the inner region of the ciliary gating zone
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    of both KIFC1 and KIF17 in preeclamptic (PE), and diabetic-term placental tissues, might suggest that these proteins may be involved in complex trophoblast functions and placental pathologie
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS