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FLASH GENE
Symbol KIF16B contributors: mct - updated : 13/10/2008
HGNC name kinesin family member 16B
HGNC id 15869
Location 20p11.23      Physical location : 16.252.748 - 16.554.078
Synonym name
  • sorting nexin 23
  • chromosome 20 open reading frame 23
  • Synonym symbol(s) FLJ20135, dJ971B4.1, SNX23, FLJ23045, KIAA1590, KISC20ORF, c20orf23
    DNA
    TYPE functioning gene
    STRUCTURE 301.33 kb     26 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 5274 - 1317 - Miki (2005)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
     parathyroid   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • a phox homology (PX) domain
  • a FHA domain
  • a kinesin-motor domain
  • HOMOLOGY
    Homologene
    FAMILY
  • sorting nexin family
  • kinesin-like protein family, kinesin-3 family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    text microtubule associated complex
    basic FUNCTION
  • involved in several stages of intracellular trafficking
  • modulating the intracellular localization of early endosomes and the balance between receptor recycling and degradation
  • acting as a microtubule motor
  • attaches to the membrane of early endosomes, regulates the motility of these organelles, and is required for efficient EGF receptor recycling from early endosomes to cell membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • intracellular signaling cascade
  • microtubule-based movement
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide, other,
  • phosphoinositides
  • ATP
  • protein
  • PTPN21 endosomal localization is mediated by interaction with KIF16B, an endosomal kinesin that modulates receptor recycling at the plasma membrane
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS