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FLASH GENE

Symbol

KIF13B

contributors: shn/npt/pgu - updated : 15-10-2017

HGNC name	kinesin family member 13B
HGNC id	14405

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8p21.1      Physical location : 28.924.795 - 29.120.610
Synonym name	guanylate kinase associated kinasin 13 B
	gakin
	kinesin-like protein GAKIN
Synonym symbol(s)	KIAA0639, GAKIN

DNA

TYPE	functioning gene
STRUCTURE	195.82 kb     40 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015254 40 - 8774 NP_056069 203 1826 - 2007 17696365

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       lowly Digestive intestine small intestine     lowly   intestine large intestine colon   lowly   liver       lowly Endocrine pancreas       highly Lymphoid/Immune spleen       lowly   thymus       lowly Nervous brain limbic system hippocampus   highly Homo sapiens Reproductive female system placenta     lowly   female system ovary     lowly   male system prostate     moderately   male system testis     moderately Respiratory lung       lowly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   lowly

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage
cell lines	Jurkat T cells
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a motor domain at the NH(2) terminus
	a central stalk domain
	a FHA domain of KIF13B interacts with the PH1 domain of one ADAP1
	a putative microtubule-interacting sequence called the CAP-Gly domain at the COOH terminus

conjugated

PhosphoP

HOMOLOGY

interspecies	ortholog to kif13B, Rattus norvegicus
	ortholog to kif13B, Mus musculus
	ortholog to kif13b, Danio rerio
	ortholog to KIF13B, Pan troglodytes

intraspecies

homolog to kinesin 73 motor protein

Homologene

FAMILY

kinesin superfamily of motor proteins

CATEGORY

motor/contractile , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule
text	KIF11, 21B, 13B with distinct effects on synaptic transmission are expressed in the same hippocampal neuron

basic FUNCTION	playing a role in the intracellular trafficking of MAGUK
	exhibits potent microtubule gliding activity but has little microtubule-stimulated ATPase activity in solution, suggesting that it exists in an autoinhibitory form
	kinesin-like motor protein, that directly interacts with a PIP3-interacting protein, PIP3BP, and mediates the transport of PIP3-containing vesicles
	key intermediate, linking MARK2 to the regulation of axon formation
	negatively regulates TCR signaling to NF-KB, associates with CARD11 in a signal-dependent manner and can compete with the required signaling protein, BCL10, for association
	dynamically localizes to the immunological synapse and regulates the redistribution of CARD11 from the central region of the synapse to a distal region

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component	GAKIN-PIP3BP complex transports PIP3 to the neurite ends and regulates neuronal polarity formation
	KIF13B and ADAP1 form heterotetramers that can bind four phosphoinositide molecules in the vesicle and transport it along the microtubule

INTERACTION

DNA

RNA

small molecule

protein	DLG (disc large tumor suppressor) guanylate-kinase-like domain of PSD95
	DLG1
	interacts with ADAP1 through its forkhead-associated (FHA) domain
	KIF13A and KIF13B are novel RAB10-interacting proteins
	and RAB10 regulates tubular endosome formation through KIF13A and KIF13B motors

cell & other

REGULATION

Other

regulated by the direct binding of its protein cargo, discs large (hDlg) tumor suppressor

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS