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FLASH GENE
Symbol KIF13B contributors: shn/npt/pgu - updated : 15-10-2015
HGNC name kinesin family member 13B
HGNC id 14405
Location 8p21.1      Physical location : 28.924.795 - 29.120.610
Synonym name
  • guanylate kinase associated kinasin 13 B
  • gakin
  • kinesin-like protein GAKIN
  • Synonym symbol(s) KIAA0639, GAKIN
    DNA
    TYPE functioning gene
    STRUCTURE 195.82 kb     40 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    40 - 8774 203 1826 - 2007 17696365
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveintestinesmall intestine  lowly
     intestinelarge intestinecolon lowly
     liver   lowly
    Endocrinepancreas   highly
    Lymphoid/Immunespleen   lowly
     thymus   lowly
    Nervousbrainlimbic systemhippocampus highly Homo sapiens
    Reproductivefemale systemplacenta  lowly
     female systemovary  lowly
     male systemprostate  moderately
     male systemtestis  moderately
    Respiratorylung   lowly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal lowly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines Jurkat T cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a motor domain at the NH(2) terminus
  • a central stalk domain
  • a FHA domain of KIF13B interacts with the PH1 domain of one ADAP1
  • a putative microtubule-interacting sequence called the CAP-Gly domain at the COOH terminus
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to kif13B, Rattus norvegicus
    ortholog to kif13B, Mus musculus
    ortholog to kif13b, Danio rerio
    ortholog to KIF13B, Pan troglodytes
    intraspecies homolog to kinesin 73 motor protein
    Homologene
    FAMILY
  • kinesin superfamily of motor proteins
  • CATEGORY motor/contractile , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • KIF11, 21B, 13B with distinct effects on synaptic transmission are expressed in the same hippocampal neuron
  • basic FUNCTION
  • playing a role in the intracellular trafficking of MAGUK
  • exhibits potent microtubule gliding activity but has little microtubule-stimulated ATPase activity in solution, suggesting that it exists in an autoinhibitory form
  • kinesin-like motor protein, that directly interacts with a PIP3-interacting protein, PIP3BP, and mediates the transport of PIP3-containing vesicles
  • key intermediate, linking MARK2 to the regulation of axon formation
  • negatively regulates TCR signaling to NF-KB, associates with CARD11 in a signal-dependent manner and can compete with the required signaling protein, BCL10, for association
  • dynamically localizes to the immunological synapse and regulates the redistribution of CARD11 from the central region of the synapse to a distal region
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • GAKIN-PIP3BP complex transports PIP3 to the neurite ends and regulates neuronal polarity formation
  • KIF13B and ADAP1 form heterotetramers that can bind four phosphoinositide molecules in the vesicle and transport it along the microtubule
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DLG (disc large tumor suppressor) guanylate-kinase-like domain of PSD95
  • DLG1
  • interacts with ADAP1 through its forkhead-associated (FHA) domain
  • cell & other
    REGULATION
    Other regulated by the direct binding of its protein cargo, discs large (hDlg) tumor suppressor
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS