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FLASH GENE
Symbol KIF13A contributors: mct - updated : 30-05-2023
HGNC name kinesin family member 13A
HGNC id 14566
Location 6p22.3      Physical location : 17.760.584 - 17.987.799
Synonym name
  • homolog of mouse KIF13A mannose-6-phosphate receptor transporter
  • kinesin-like protein RBKIN
  • Synonym symbol(s) RBKIN, bA500C11.2, FLJ27232
    DNA
    TYPE functioning gene
    STRUCTURE 228.51 kb     38 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4690 - 659 keart, skeletal muscle, fetal muscle 2022 35122963
    lack of exon36-37
    38 - 7153 - 1749 - 2022 35122963
  • KIN13A2
  • lack of exon 37
  • 37 - 5863 - 1757 heart, skeletal muscle, fetal muscle 2022 35122963
  • KIN13A1
  • lack of exon 36
  • 38 - 5902 - 1770 - 2022 35122963
    39 - 6007 - 1805 - 2022 35122963
    3 - 1342 - 70 - 2022 35122963
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon  
    Endocrinepancreas    
    Nervousbrain   highly
    Reproductivemale systemprostate   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines retinoblastoma cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text kidney, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminus with motor and stalk domain
  • consensus ATP/GTP binding site
  • a forkhead-associated (FHA) domain of KIF13A
  • NC-CC1 domains
  • variable C terminal domain
  • HOMOLOGY
    interspecies homolog to kif13a mannose 6 phosphate receptor transporter
    ortholog to Drosophila kinesin 73
    Homologene
    FAMILY
  • kinesin-3 family
  • CATEGORY protooncogene , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    basic FUNCTION
  • involved in the transport of specific synaptic vesicles
  • contributing to malignant progression of retinoblastoma
  • role for this molecular motor in anxiety control
  • KIF13A associates with recycling endosome tubules and controls their morphogenesis
  • KIF13A plays an important role in the transport of influenza A vRNPs, a crucial step for viral assembly
  • KIF13A motors are tuned at a single-molecule level to function as weak dimers on the cellular cargo
  • implicated in several processes in many cell types, including cargo transport, recycling endosomal tubule biogenesis, cell polarity, migration and cytokinesis
  • is a key regulator of recycling endosome dynamics
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cell to cell transport
    PATHWAY
    metabolism
    signaling
    a component
  • RAB22A forms a complex with BLOC1S1, BLOC1S2 and the kinesin-3 family motor KIF13A on endosomes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BLOC1S1 coordinates the kinesin KIF13A-dependent pulling of endosomal tubules along microtubules to the ANXA2/actin-dependent stabilization and detachment of recycling tubules
  • MTOR regulates M6PR transport and T-cell vulnerability to regulatory T cells controlling kinesin KIF13A
  • KIF13A and KIF13B are novel RAB10-interacting proteins, and RAB10 regulates tubular endosome formation through KIF13A and KIF13B motors
  • RAB22A plays an unusual role by binding to NC-CC1 domains of KIF13A, relieving proline-mediated inhibition and facilitating motor dimerization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    KIF13A-RET fusion in lung adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS