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FLASH GENE

Symbol

KIF13A

contributors: npt/ - updated : 17-12-2003

HGNC name	kinesin family member 13A
HGNC id	14566

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p23      Physical location : 17.760.584 - 17.987.799
Synonym name	homolog of mouse KIF13A mannose-6-phosphate receptor transporter
	kinesin-like protein RBKIN
Synonym symbol(s)	RBKIN, bA500C11.2, FLJ27232

DNA

TYPE	functioning gene
STRUCTURE	227.21 kb     38 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

cytosine-phosphate-guanine/HTF

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed KIN13A2 - - 5740 - 1749 - Jamain lack of exon 37 KIN13A1 - - 5110 - 1757 heart, skeletal muscle, fetal muscle Jamain lack of exon 36 KIN13? - - 4690 - 659 keart, skeletal muscle, fetal muscle Jamain lack of exon36-37

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine large intestine colon     Endocrine pancreas         Nervous brain       highly Reproductive male system prostate       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage
cell lines	retinoblastoma cell lines
fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	kidney, placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminus with motor and stalk domain
	consensus ATP/GTP binding site
	variable C terminal domain

HOMOLOGY

interspecies	homolog to kif13a mannose 6 phosphate receptor transporter
	ortholog to Drosophila kinesin 73

Homologene

FAMILY

kinesin-like protein family

CATEGORY

protooncogene , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule
	intracellular,nucleus

basic FUNCTION	involved in the transport of specific synaptic vesicles
	contributing to malignant progression of retinoblastoma

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cell to cell transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS