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FLASH GENE
Symbol KIF11 contributors: mlc/npt/pgu - updated : 27-09-2011
HGNC name kinesin family member 11
HGNC id 6388
Corresponding disease
MLCD2 microcephaly, lymphedema, chorioretinopathy syndrome 2
Location 10q24.1      Physical location : 94.352.824 - 94.415.150
Synonym name
  • thyroid receptor interacting protein 5
  • kinesin-like 1
  • kinesin-like spindle protein HKSP
  • Synonym symbol(s) EG5, KHR1, TRIP5, KNSL1, HKSP
    DNA
    TYPE functioning gene
    STRUCTURE 62.33 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    HTR7 10q22-q24 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) RPP30 10q23.32-q23.33 ribonuclease P (30kD) ANKRD1 10q23.33 ankyrin repeat domain 1 (cardiac muscle) LOC387701 10 LOC387701 MGC34007 10q23.33 hypothetical protein MGC34007 MGC16202 10q23.33 hypothetical protein MGC16202 FLJ37306 10q23.32 hypothetical protein FLJ37306 LOC387702 10 similar to hypothetical protein FLJ25224 PPP1R3C 10q23-q24 protein phosphatase 1, regulatory (inhibitor) subunit 3C LOC389995 10 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) TNKS2 10q23.3 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 C10orf13 10q23.33 chromosome 10 open reading frame 13 BTAF1 10q22-q23 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae) CPEB3 10q23.33 cytoplasmic polyadenylation element binding protein 3 FLJ20445 10q23.33 hypothetical protein FLJ20445 LOC389996 10 similar to MAP/microtubule affinity-regulating kinase 2 isoform a; ELKL motif kinase 1; ELKL motif kinase IDE 10q24 insulin-degrading enzyme KIF11 10q24.1 kinesin family member 11 LOC283014 10q23.33 similar to eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; eukaryotic translation initiation factor 2, subunit 2 (beta, 38kD ); eukaryotic initiation factor 2-beta HHEX 10q24 hematopoietically expressed homeobox SEC15L1 10q23.33 SEC15-like 1 (S. cerevisiae) CYP26C1 10q23.33 cytochrome P450, family 26, subfamily C, polypeptide 1 CYP26A1 10q23-q24 cytochrome P450, family 26, subfamily A, polypeptide 1 LOC389997 10 similar to Saccharomyces cerevisiae Nip7p homolog LOC387703 10 similar to ATP-dependent DNA helicase II, 70 kDa subunit (Lupus Ku autoantigen protein p70) (Ku70) (70 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box binding factor 75 kDa subunit) (CTCBF) (CTC75) LOC389998 10 similar to 60S ribosomal protein L17 (L23) FER1L3 10q23.3 fer-1-like 3, myoferlin (C. elegans) C10orf3 10q23.33 chromosome 10 open reading frame 3 GPR120 10q23.33 G protein-coupled receptor 120 RBP4 10q24 retinol binding protein 4, plasma PDE6C 10q24 phosphodiesterase 6C, cGMP-specific, cone, alpha prime C10orf4 10q23.33 chromosome 10 open reading frame 4 LGI1 10q24 leucine-rich, glioma inactivated 1 FLJ33990 10q23.33 hypothetical protein FLJ33990 PSMD4P2 10q23.33 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4, pseudogene 2 PLCE1 10q23 phospholipase C, epsilon 1 AD24 10q23.33 AD24 protein KIAA0608 10q23.33 KIAA0608 protein HELLS 10q23-q24 helicase, lymphoid-specific CYP2C18 10q24 cytochrome P450, family 2, subfamily C, polypeptide 18 CYP2C19 10q24 cytochrome P450, family 2, subfamily C, polypeptide 19 CYP2C9 10q24.1 cytochrome P450, family 2, subfamily C, polypeptide 9 CYP2C8 10q23.33 cytochrome P450, family 2, subfamily C, polypeptide 8
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 5101 119 1056 - 2011 21522128
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, M
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a highly conserved N-terminal catalytic motor domain that can hydrolyze ATP to move processively toward the plus ends of microtubules
  • a kinesin-motor domain, with TNXB-binding region
  • an ATP and a microtubule binding sites
  • a central coiled-coil domain
  • a C-terminal tail that contains a bimC box, a conserved sequence of positively charged amino acid residues, implicated in contact with microtubules
  • mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to Xenopus eg5
    homolog to rattus Kif11
    Homologene
    FAMILY
  • kinesin-like protein family, kinesin-5 family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • TNXB and KIF11 proteins were co-localized in the cytoplasm in interphase and mitosis, but TNXB did not localize on mitotic spindle microtubules, on which KIF11 prominently localized in mitosis
  • localizes to spindle microtubules during mitosis
  • basic FUNCTION
  • mitotic spindle assembly
  • microtubule motor activity
  • involved in chromosome positioning, centrosome separation, establishing a bipolar spindle during mitosis
  • plus-end-directed motor involved in separation of centrosomes, and in bipolar spindle formation and maintenance during mitosis
  • having essential and nonredundant functions that are necessary for cell viability and early embryonic development
  • critical for spindle assembly during mitosis and has recently been implicated in tumorigenesis
  • functions as a homotetramer, with two motor domains at each end of a central stalk, and contributes to spindle assembly by cross-linking and pushing apart adjacent interpolar microtubules
  • permits microtubules to selectively invade one side of the growth cone by opposing their entry into the other side
  • critical for proper spindle assembly and represents an attractive anticancer target
  • RARRES1, AGBL2, KIF11, another EEY-bearing protein (EB1), and the microtubule tyrosination cycle are important in tumorigenesis
  • actin-dependent KIF11-opposing forces slow down separation in G2 phase
  • role of KIF11, PLK1 and the NIMA-family kinases in the control of centrosome separation and normal mitotic progression
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text formation and maintenance of mitotic spindle
    PATHWAY
    metabolism
    signaling
    a component
  • homotetrameric, slow-processive, plus-end-directed spindle motor protein
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with the thyroid hormone receptor in the presence of T3
  • NPM1 directly interacts with KIF11, in the cytosol (NPM1 acts as an upstream regulator of KIF11 in promoting microtubule polymerization)
  • poleward transport requires the C terminus of TPX2, a domain that interacts with KIF11
  • interaction with LMNB1 (LMNB1 only very weakly antagonizes KIF11 in mediating poleward microtubule-flux
  • interaction with PLK1 (PLK1 is required for both CEP250 displacement and for KIF11 localization on the centrosome)
  • interacts with the spindle assembly factor TPX2 (this interaction was required for kinetochore fiber formation and contributed to KIF11 localization to spindle microtubules but not spindle poles)
  • cell & other
  • microtubule associated
  • REGULATION
    inhibited by by Parkin (PARK2), an E3 ubiquitin ligase well known for its role in the development of Parkinson disease
    Other CDC2, regulating KNSL1 localization
    phosphorylated only on serine during S phase, and on serine and threonine during mitosis
    ASSOCIATED DISORDERS
    corresponding disease(s) MLCD2
    Susceptibility to type 2 diabetes
    Variant & Polymorphism other polymorphism increasing the risk of type 2 diabetes
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    KIF11 inhibitors, when able to permeate the blood-brain-barrier, could represent an interesting class of anticancer drugs with low neurotoxic effects in the treatment of brain tumors
    ANIMAL & CELL MODELS