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FLASH GENE
Symbol KIAA1549 contributors: mct/npt - updated : 01-09-2009
HGNC name KIAA1549
HGNC id 22219
Location 7q34      Physical location : 138.516.128 - 138.666.064
Synonym name hypothetical protein LOC57670
Synonym symbol(s) FLJ11731, FLJ38703, FLJ40644
DNA
TYPE functioning gene
STRUCTURE 88.44 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC392100 7 similar to protease (prosome, macropain) 26S subunit, ATPase 1 LOC389559 7 LOC389559 CHRM2 7q31-q35 cholinergic receptor, muscarinic 2 LOC389560 7 LOC389560 PTN 7q33-q34 pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) DGKI 7q32.3-q33 diacylglycerol kinase, iota CREB3L2 7q33-q34 cAMP responsive element binding protein 3-like 2 AKR1D1 7q32-q33 aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) LOC392101 7 similar to dJ753D5.2 (novel protein similar to RPS17 (40S ribosomal protein S17)) LOC392102 7 similar to prothymosin, alpha (gene sequence 28) LOC136307 7q34 similar to inosine monophosphate dehydrogenase 1 isoform b; sWSS2608 TIF1 7q32-q34 transcriptional intermediary factor 1 LOC136306 7q34 hypothetical protein LOC136306 LOC392103 7 similar to 60S ribosomal protein L17 (L23) LOC202789 7q34 similar to Ubiquinol-cytochrome C reductase iron-sulfur subunit, mitochondrial precursor (Rieske iron-sulfur protein) (RISP) ATP6V0A4 7q33-q34 ATPase, H+ transporting, lysosomal V0 subunit a isoform 4 KIAA1549 7q34 KIAA1549 protein MGC14289 7q34 similar to RIKEN cDNA 1200014N16 gene ZC3HAV1 7q34 zinc finger CCCH type, antiviral 1 FLJ12571 7q34 hypothetical protein FLJ12571 LOC389561 7 similar to 60S ribosomal protein L37a FLJ25778 7q34 hypothetical protein FLJ25778 HSPC268 7q34 hypothetical protein HSPC268 LUC7L2 7q34 LUC7-like 2 (S. cerevisiae) FLJ44186 7q34 FLJ44186 protein LOC392104 7 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein HIPK2 7q32-q34 homeodomain interacting protein kinase 2 LOC389562 7 LOC389562 TBXAS1 7q34-q35 thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) ZC3HDC1 7q34 zinc finger CCCH type domain containing 1 SLC37A3 7q34 solute carrier family 37 (glycerol-3-phosphate transporter), member 3 LOC389563 7 similar to RAB19, member RAS oncogene family LOC392105 7 similar to Nucleoside diphosphate kinase, mitochondrial precursor (NDP kinase, mitochondrial) (NDK) (nm23-M4) (Nucleoside diphosphate kinase D) MKRN1 7q34 makorin, ring finger protein, 1 KIAA1277 7q34 KIAA1277 ADCK2 7q32-q34 aarF domain containing kinase 2 NDUFB2 7q34-q35 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa BRAF 7q34 v-raf murine sarcoma viral oncogene homolog B1 MRPS33 7q32-q34 mitochondrial ribosomal protein S33
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 12379 - 1934 - Jones (2008)
- - 12427 - 1950 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION unknown
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
Tandem duplication at 7q34 leading to a fusion between KIAA1549 and BRAF occurs in the majority of Pilocytic astrocytomas (Jones 2009)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS