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FLASH GENE
Symbol KIAA1161 contributors: shn/npt - updated : 27-05-2010
HGNC name KIAA1161
HGNC id 19918
Location 9p13.3      Physical location : 34.368.907 - 34.376.894
Synonym name hypothetical protein LOC57462
Synonym symbol(s) NET37
EC.number 3.2.1.-
DNA
TYPE functioning gene
STRUCTURE 7.99 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D9S1817 - D9S1805 - KIAA1161 - D9S1804 - D9S1794 - cen
Physical map
UBE2R2 9p11.2 ubiquitin-conjugating enzyme E2R 2 UBAP2 9p13.2 ubiquitin associated protein 2 KIAA1892 9p11.2 KIAA1892 LOC340499 9p13.2 similar to inosine monophosphate dehydrogenase 1 isoform b; sWSS2608 UBAP1 9p22-p21 ubiquitin associated protein 1 C9orf48 9p13.2 chromosome 9 open reading frame 48 KIF24 9p13.2 kinesin family member 24 NUDT2 9p13 nudix (nucleoside diphosphate linked moiety X)-type motif 2 KIAA1161 9p11.2 KIAA1161 C9orf24 9p11.2 chromosome 9 open reading frame 24 C9orf25 9p11.2 chromosome 9 open reading frame 25 DNAI1 9p13.3 dynein, axonemal, intermediate polypeptide 1 UNQ470 9p13.2 GAAI470 CNTFR 9p21-p13 ciliary neurotrophic factor receptor C9orf23 9p11.2 chromosome 9 open reading frame 23 DCTN3 9p13 dynactin 3 (p22) LOC138715 9p13.2 similar to E2F binding protein OPRS1 9 opioid receptor, sigma 1 GALT 9p13.3 galactose-1-phosphate uridylyltransferase IL11RA 9p13 interleukin 11 receptor, alpha CCL27 9p13 chemokine (C-C motif) ligand 27 LOC389714 9 LOC389714 CCL19 9p13 chemokine (C-C motif) ligand 19 CCL21 9p13 chemokine (C-C motif) ligand 21 LOC259308 9p12 DKFZP434J193-like pseudogene
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 4205 - 714 highly expressed in muscle Datta (2009)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single transmembrane domain at the N terminus
  • a family 31 glycosyl hydrolase domain at the C terminus
  • HOMOLOGY
    interspecies homolog to AI464131, Mus musculus
    ortholog to RGD1309821, Rattus norvegicus
    homolog to LOC556083, Danio rerio
    Homologene
    FAMILY
  • glycosyl hydrolase family 31
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION intracellular,nuclear envelope
    basic FUNCTION
  • required for efficient myoblast differentiation (Datta et al, 2009)
  • a role in IGF-II maturation in the secretory pathway during myoblast differentiation (Datta et al, 2009)
  • may mediate transmembrane communication between the ER lumen and the nuclear interior during myoblast differentiation (Datta et al, 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • pro-form of the insulin-like growth factor 2 (Datta et al, 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS