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FLASH GENE
Symbol KIAA0020 contributors: mct - updated : 07-09-2011
HGNC name KIAA0020
HGNC id 29676
Location 9p24.2      Physical location : 2.804.154 - 2.844.130
Genatlas name penguin homolog (Drosophila)
Synonym name
  • minor histocompatibility antigen HA-8
  • protein 5 transactivated by hepatitis B virus X antigen (HBxAg)
  • Synonym symbol(s) XTP5, MGC8749, PEN, PUF6, HLA-HA8, PUF-A
    DNA
    TYPE functioning gene
    STRUCTURE 39.98 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 2232 - 648 - 2001 11148223
    - - 2112 57.4 508 - Brickner (2001)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     liver    
    Reproductivefemale systemuterus   
     female systemovary   
     male systemtestis   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one PUM-HD domain
  • six pumilio repeats
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • predominantly localized in the nucleoli with minor punctate signals in the nucleoplasm
  • basic FUNCTION
  • minor histocompatibility antigen
  • polymorphic peptides presented to T lymphocytes restricted by the MHC molecule
  • may regulate cellular response to genotoxic stress by inhibiting PARP1 activity and thus preventing PARP1 degradation by caspase-3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with PARP1 (specifically interacts with the catalytic domain of PARP1 and inhibits poly(ADP-ribosylation of PARP1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS