Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol KDM4D contributors: mct - updated : 17-04-2013
HGNC name lysine (K)-specific demethylase 4D
HGNC id 25498
Location 11q21      Physical location : 94.706.844 - 94.732.674
Synonym name jumonji domain containing 2D
Synonym symbol(s) FLJ10251, JMJD2D, JHDM3D, MGC141909
EC.number 1.14.11.-
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text clustered with JMJD2F and JMJD2E
STRUCTURE 25.83 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2988 - 523 - 2004 15138608
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuterus   
 male systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single predicted JmjN domain to the N terminus of the JmjC domain,
  • one arid domain
  • one jmjc domain
  • two phd-type zinc fingers
  • lacking the dual PHD and Tudor domains characteristic of KDM4AC
  • HOMOLOGY
    interspecies homolog to rattus LOC315429
    Homologene
    FAMILY
  • JMJD2 family
  • JHDM3 histone demethylase family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in spermatogenesis
  • demethylation of H3K9me3 in round spermatids is dispensable for spermatogenesis but possible defects in KDM4D-null elongating spermatids could be rescued by functional redundancy of the KDM4B demethylase
  • a KDM4D type activity is important in eutherian biology
  • histone demethylase that removes methyl moieties from lysine 9 on histone 3 and from lysine 26 on histone 1.4
  • can stimulate cell proliferation and survival, suggesting that its inhibition may be helpful in the fight against cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a complex with the TP53 tumor suppressor
  • KDM4A and KDM4D, form complexes with ligand-bound AR
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TP53
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS