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FLASH GENE
Symbol KDM2B contributors: mct - updated : 24-11-2011
HGNC name lysine (K)-specific demethylase 2B
HGNC id 13610
Location 12q24.31      Physical location : 121.866.901 - 122.018.920
Synonym name
  • protein containing CXXC domain 2
  • JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein
  • jumonji C domain-containing histone demethylase 1B
  • F-box and leucine-rich repeat protein 10
    • Synonym symbol(s) CXXC2, PCCX2, JHDM1B, FBXL10, Fbl10, NDY1
    DNA
    TYPE functioning gene
    STRUCTURE 152.02 kb     23 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 5236 - 1265 - 2007 17994099
    23 - 5318 - 1336 - 2007 17994099
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselsaorta   
    Digestivestomach   highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a F-box domain
  • a jmjC domain, necessary for the specific demethylation of trimethylated lysine 4 on histone H3 in the nucleolus
  • two leucine-rich repeats
  • a CXXC-type zinc finger
    • HOMOLOGY
    interspecies homolog to murine Fbxl10
    intraspecies paralog to the histone demethylase KDM2A
    Homologene
    FAMILY JHDM (JmjC-domain-containing histone demethylase) family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • putative role in chromatin remodeling
  • playing a role in cancer development
  • negatively regulates rRNA gene expression
  • H3K36 demethylase that regulates cell proliferation and senescence through CDKN2B
  • JmjC domain-containing histone demethylase protecting cells from replicative senescence
  • regulates redox homeostasis and protects cells from oxidative stress
  • novel functional role for KDM2B as an anti-apoptotic molecule
  • transcriptional repressor of FOS and a target gene of nuclear factor kappa-light-chain-enhancer of activated B cells
  • having negative effect on cell size and cell proliferation
  • important in regulating cell proliferation and cellular senescence
  • potentially functioning as an oncogene and playing a critical role in leukemia development and maintenance
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    oncogenic pathway that functionally links FGF2 with EZH2 via KDM2B and miR-101
    a component
    INTERACTION
    DNA preferentially binds the transcribed region of ribosomal DNA to repress the transcription of ribosomal RNA genes
    RNA
    small molecule nucleotide,
  • ATP binding
  • Zn2+ binding
    • protein
  • synergizes with EZH2 to silence the EZH2 inhibitor miR-101
    • cell & other
    REGULATION
    induced by FGF2 via CREB phosphorylation and activation, downstream of DYRK1A, and mediates the FGF2 and EZH2 effects on cell proliferation, migration, and angiogenesis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in various human leukemias
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    silencing KDM2B can help overcome resistant cancer cells for pro-apoptotic therapies
    ANIMAL & CELL MODELS
  • about half of Fbxl10-deficient mice exhibit failure of neural tube closure, resulting in exencephaly and die shortly after birth