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FLASH GENE
Symbol KDELR2 contributors: mct - updated : 29-05-2019
HGNC name KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
HGNC id 6305
Location 7p22.1      Physical location : 6.500.712 - 6.523.849
Synonym name
  • ERD-2-like protein
  • ER lumen protein-retaining receptor 2
  • ERD2-like protein 1
  • KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
  • Synonym symbol(s) ELP1, ERD2-2, ELP-1, ERD2.2, FLJ45532
    DNA
    TYPE functioning gene
    STRUCTURE 23.14 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D7S481 - KDELR2 - D7S2553 - D7S2464 - cen
    Authors Gene Map (98)
    Physical map
    KDELR2 7p22-p21 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 FLJ20306 7p22.2 hypothetical protein FLJ20306 LOC392861 7 similar to ribosomal protein L31 LOC392862 7 similar to GluR-delta2 philic-protein USP42 7p22.2 ubiquitin specific protease 42 PIK3CG 7q21.11 phosphoinositide-3-kinase, catalytic, gamma polypeptide PSCD3 7q21 pleckstrin homology, Sec7 and coiled-coil domains 3 ZDHHC4 7p22.2 zinc finger, DHHC domain containing 4 C7orf26 7p22.1 chromosome 7 open reading frame 26 LOC392626 7 similar to zinc finger protein 316; kruppel-related zinc finger protein; transcription factor MZF-3 LOC392627 7 LOC392627 PRKAR2B 7q22-q31.1 protein kinase, cAMP-dependent, regulatory, type II, beta ZNF325 7p22.2 zinc finger protein 325 MGC12966 7p22.2 hypothetical protein MGC12966 LOC392628 7 hypothetical gene supported by AB116525; NM_000535 RAC1 7p22 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) LOC221955 7p22.2 KCCR13L C7orf28B 7p22.2 chromosome 7 open reading frame 28B HBP1 7q22-q31 HMG-box transcription factor 1 LOC392863 7 similar to olfactory receptor MOR145-1 COG5 7q31 component of oligomeric golgi complex 5 KDELR2 7p22-p21 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 LOC392629 7 similar to unc-93 homolog B1; unc93 (C.elegans) homolog B; unc-93 related protein LOC392864 7 hypothetical gene supported by AK122996 FLJ20306 7p22.2 hypothetical protein FLJ20306 LOC391999 7 similar to ribosomal protein L31 LOC340265 7p22.2 similar to GluR-delta2 philic-protein LOC392865 7 similar to Asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase) LOC392866 7 similar to hypothetical protein FLJ10661 ZDHHC4 7p22.2 zinc finger, DHHC domain containing 4 C7orf26 7p22.1 chromosome 7 open reading frame 26 LOC389461 7 similar to zinc finger protein 316; kruppel-related zinc finger protein; transcription factor MZF-3 ZNF325 7p22.2 zinc finger protein 325 LOC392867 7 similar to vav-1 interacting Kruppel-like protein isoform a GPR22 7q22-q31.1 G protein-coupled receptor 22
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 2874 24.3 212 - 2015 25682866
    4 splicing 2621 21.2 186 - 2015 25682866
  • lacking an exon in the coding region compared to variant 1 which results in a frameshift
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestiveintestine   highly
     stomach   highly
    Endocrineadrenal gland   moderately
    Hearing/Equilibriumear   moderately
    Reproductivefemale systembreastmammary gland moderately
     female systemuteruscervix moderately
     female systemplacenta  highly
     male systemprostate  moderately
     male systemtestis  moderately
    Skin/Tegumentskin   highly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text moderately in umbilical cord, highly in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Kdelr2 (98.6 pc)
    homolog to murine Kdelr2 (98.6 pc)
    intraspecies homolog to KDELR 1
    Homologene
    FAMILY
  • KDELR family
  • ERD2 family
  • CATEGORY receptor membrane G , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • multi-pass membrane protein
  • at the Golgi, KDELR1, KDELR2 acts as a traffic sensor (presumably via binding to chaperones that leave the ER) and triggers signalling pathways that balance membrane fluxes between ER and Golgi
  • basic FUNCTION
  • allowing the retrieval of proteins from Golgi complex to ER
  • mediating a retrieval mechanism contributing to quality control at the RE
  • required for the retention of luminal endoplasmic reticulum proteins
  • determining the specificity of the luminal ER protein retention system
  • required for normal vesicular traffic through the Golgi
  • KDELR2 competes with MV envelope proteins for binding to calnexin and HSPA5, and this interaction limits the availability of the chaperones for Measles Virus (MV) proteins, causing the reduction of virus spread and titers
  • KDELR1, KDELR2 regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • protein transport
  • Er-Golgi transport
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KDELR1, KDELR2 activates CREB1 and other transcription factors that upregulate transport-related genes
  • KDELR1, KDELR2 induces SRC activation at the invadopodia and leads to phosphorylation of the SRC substrates cortactin and ASAP1, which are required for basal and KDELR-stimulated ECM (extracellular matrix) degradation
  • PHB can act as a signalling scaffold protein to assist in KDELR1, KDELR2-dependent Src activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    mimicking the brefeldin A (BFA)-like phenotype
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS